نتایج جستجو برای: drug dependence
تعداد نتایج: 736814 فیلتر نتایج به سال:
The aims of the present study were to assess preparedness and function of health system in the management of withdrawal symptoms in opioid dependents after Bam earthquake, the methods that medical staff used for identification of dependents, the viewpoints of the medical staff as well as opioid dependents about the roles of health system, and the appropriate methods for managing opioid dependen...
one of the applications of nanotechnology is use of carbon nanotubes for the targeted delivery of drug molecules. to demonstrate the physical and chemical properties of biomolecules and identify new material of drug properties, the interaction of carbon nanotubes (cnts) with biomolecules is a subject of many investigations. cnts is a synthetic compound with extraordinary mechanical, thermal, el...
recent studies on rodents showed successful treatment outcomes for cocaine dependence by using buprenorphine and naltrexone without the risk of dependence on them. such findings could provide a new hope on treatment of cocaine, methamphetamine or other stimulants dependence. the idea of using these medicines was formed once dr. nora volkow (director of nation institute for drug abuse) based on ...
Drug abuse and dependence have progressively become a dramatic problem in human societies. Since the exact mechanism(s) of the effect of related drugs in the brain has not been explored, therefore, this problem has not been resolved yet. Several lines of evidence indicated that nitric oxide (NO) plays an important role in the process of drug dependence. The role of NO within the different regio...
Introduction: Heroin dependence is a chronic relapsing disorder caused by a combination of genetic, epigenetic, and environmental factors. The genetic contribution in the vulnerability to heroin dependence is 40%-60%. Alterations in dopamine transport in the CNS are implicated in drug and alcohol dependence, and according to linkage studies, the HTR2A rs6313 single nucleotide polymorphism plays...
BACKGROUND: Alcoholism is characterized by impaired decision-making (i.e., choosing intoxication in the face of mounting negative consequences). This impairment may involve a reduced brain response to the negative consequences of behavior, which supports an inclination to engage in risky behaviors. The feedback error-related negativity (F-ERN) is hypothesized to reflect the valence attached to ...
Subjects, methods, and results In 1988-9 we interviewed a random sample of 1751 men serving a prison sentence (5% of the population) about drug use in the six months before arrest. Dependence on a drug was defined as in the previous study. Drug users were asked about previous contact with treatment agencies and their current attitude towards treatment. A question about drug use within prison wa...
Background: Cocaine use, abuse and dependence remains a pressing public health problem. Based on its mechanism of action, varenicline, an alpha4beta2 partial agonist seemed to be a likely candidate for treating cocaine dependence. Methods: Cocaine dependent participants (n = 37) were enrolled in a 9-week double-blind placebo controlled clinical trial. Varenicline was titrated up to a target dos...
Drug-dependence disorders (we focus here on cocaine, opioid, and nicotine dependence) are genetically influenced. Risk genes have been located based primarily on genetic linkage studies, and identified primarily based on genetic association studies. In this article we review salient results from linkage, association, and genome-wide association study methodologies, and discuss future prospects ...
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