Dolutegravir is neither an inducer nor inhibitor of metabolising enzymes, and it therefore has a low propensity to act as perpetrator drug-drug interactions. Clinically significant decreases in dolutegravir exposure occur when co-administered with strong inducers (e.g. rifampicin, efavirenz) drug enzymes efflux transporters for which substrate – this can be overcome by increasing the dose from ...

drug-drug interactions (ddis) can lead to increased toxicity or reduction in therapeutic efficacy. this study was designed to assess the incidence of potential drug interactions (pdi) and rank their clinical value in post coronary care unit (post-ccu) of a teaching hospital in tehran, iran.in this prospective study, three pharmacists with supervision of a clinical pharmacist actively gathered n...

Correct prescription writing habits could have a great influence on the fate of drug therapy as well as the health of patients. One of the major types of errors in prescriptions is the "errors of commission". In this study attempts were made to examine 519 prescriptions of the internal ward of Ayatollah Taleghani teaching hospital over a period of 3 months in terms of the nature and extent of t...

In this review, we focus on cyclic voltammetry as a reliable electrochemical technique to study mechanisms, kinetics and thermodynamics of various types of drug-drug interactions. While we present and discuss six theoretical models relevant to analyze drug-drug (or drug-DNA) interactions, we also give hints about recent experimental achievements in this field. In addition, we provide the reader...

Correct prescription writing habits could have a great influence on the fate of drug therapy as well as the health of patients. One of the major types of errors in prescriptions is the "errors of commission". In this study attempts were made to examine 519 prescriptions of the internal ward of Ayatollah Taleghani teaching hospital over a period of 3 months in terms of the nature and extent of t...

Drug-drug interaction (DDI) is one of the most important problems in the treatment of patients suffering from different chronic intractable diseases. The war-injured veterans are one of the groups that are prone to chronic refractory diseases. This investigation was conducted on war-injured veterans treated in a multi-disciplinary clinic in Tehran. Using Poisson model, a total of 150 patients w...

introduction: drug interactions are considered as adverse effects of drugs that alter a patient’s response to an initial medication due to concurrent administration of different drugs or other substances. this study aimed to assess the role of medical education in reducing potential atorvastatin drug interactions in a teaching hospital by distributing alert cards and putting up posters in a nur...

background:     purpose:     methods:     results     conclusion     rug interactions , active training : drug interactions are common medical errors in gorgan province and training can decrease their rate. keywords. d   : overall prevalence of drug interactions was 8.93%, of which 6.55% were major, 65.58% moderate and 27.87% minor. interactions were mostly seen among male doctors. the physicia...

Prescriptions written by general practitioners and medical specialists were studied and compared to determine the type, time of onset and clinical importance of drug-drug interactions (DDIs) in an attempt to reduce further complications. In 2007, 28, 956, 638 prescriptions and 15, 610, 912 prescriptions in 2008 were filled by pharmacies affiliated with medical science universities. These prescr...