Background/Aim: Drug-induced liver injury is one of the major causes acute failure. Under current circumstances pandemic COVID-19, use paracetamol which has a proven hepatotoxic effect increased. This prompts search for novel agents with hepatoprotective properties. The purpose this article was to evaluate activity cryoextract placenta (CEP) on model paracetamol-induced hepatitis. Methods: stud...

Isoniazid (INH), one of the most important drugs used in antituberculosis (anti-TB) treatment, is also the major drug involved in hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, such as NAT2, CYP2E1, GSTM1 and GSTT1, that code for drug-metabolising enzymes. Our goal was to examine the polymorphisms in these enzymes as susceptibili...

BACKGROUND The country of Georgia has a high prevalence of tuberculosis (TB) and hepatitis C virus (HCV) infection. PURPOSE To determine whether HCV co-infection increases the risk of incident drug-induced hepatitis among patients on first-line anti-TB drug therapy. METHODS Prospective cohort study; HCV serology was obtained on all study subjects at the time of TB diagnosis; hepatic enzyme ...

Apart from infectious or viral hepatitis, other most common non-infectious causes of hepatitis are alcohol, cholestatic, drugs and toxic materials. The most common mode that leads to liver injuries is antituberculosis drug-induced hepatitis. The severity of drug-induced liver injury varies from minor nonspecific changes in hepatic structure to fulminant hepatic failure, cirrhosis and liver canc...

The authors present a case report of antituberculosis drug-induced liver injury that offered diagnostic challenges (namely, the possibility of drug-induced autoimmune hepatitis) and treatment difficulties.

Hepatitis A virus (HAV) is typical enterovirus that may cause liver damage. This infection vary in intensity from a few weeks of moderate sickness to many months severe illness. It sometimes lead failure and death, especially individuals with preexisting health condition or compromised immune system. most common children developing countries. very tiny percentage those who have hepatitis die fu...