Antipsychotics (APs) are psychotropic drugs that generally have a psycholeptic effect, capable of reducing psychotic symptoms and psychomotor agitation. This class is widely used in psychiatric practice, especially for the treatment psychosis schizophrenia other disorders. Most APs pass through biotransformation process, or metabolism, after they enter body before being eliminated. There three ...

This article discusses issues related to the role of biotransformation or metabolism antipsychotics (APs) in liver. There are three phases APs metabolism. Cytochrome P450 monooxygenase, an oxidase with mixed functions, plays a key most APs, participating first phase The functional activity cytochrome enzymes depends on carriage single nucleotide variants (SNVs) genes encoding these enzymes, as ...

Abstract The focus of this chapter is on food-drug interaction in older adults. We will discuss how foods can affect drug metabolism and also vice versa drugs dietary intake nutrition status.

conclusions a review of the literature on the use of hypnotic drugs in patients with liver dysfunction showed that some hypnotic drugs used during anesthesia could be safely used in patients with impaired liver function. in these patients, certain drugs should be used with caution. results anesthesia should be performed with caution in patients with hepatic dysfunction and drugs with long half-...

the objective of the present work was to formulate and evaluate mucoadhesive in situ nasal gels of loratadine. this drug delivery system may overcome the first-pass metabolism and subsequently improve the bioavailability of the drug. a total of 16 formulations of in situ nasal gels were prepared using different polymeric ratios of hydroxypropyl methylcellulose (hpmc k-100) and xanthan gum. all ...