Synthesis on solid phase is one of modern methodologies especially useful in parallel and combinatorial syntheses. Tertiary amine functionalities are found in many important classes of catalysts, reagents and biologically active compounds. The tertiary N-methyl group is also present in structures of tropane alkaloids and majority of synthetic tropane derivatives with potential biological activi...

A large-scale, three dimensional model of the upper extremity that combines the advantages of forward and inverse dynamics is under development. The model uses inversedynamic optimization to calculate an optimal set of neural excitations for a given movement. These excitations can be used as the starting point for investigations using a forward-dynamic model, which would otherwise be prohibitiv...