Drug susceptibility testing (DST) is often needed in patients clinically failing tuberculosis (TB) therapy. Most studies of phenotypic direct drug susceptibility tests, such as microscopic observation drug susceptibility (MODS) tests, have been performed in patients not receiving TB treatment. The effect of ongoing TB treatment on the performance of MODS direct DST has not been previously explo...

CD47 is a ligand of the inhibitory receptor, signal regulatory protein (SIRP)alpha, and its interaction with SIRPalpha on macrophages prevents phagocytosis of autologous hematopoietic cells. CD47-SIRPalpha signaling also regulates dendritic cell (DC) endocytosis, activation, and maturation. In this study, we show that CD47 expression on donor cells plays an important role in suppression of allo...

Recently, there has been considerable debate on redefining Indian Standard Time (IST). The suggestions include splitting the country into two timezones, while perhaps introducing daylight saving time (DST). We argue that the IST should remain unchanged. The arguments are centred around India’s geography, nation building and practical concerns. The most compelling reason offered in favour of a n...

OBJECTIVE We evaluated the impact of an automated decision support tool (DST) on clinicians' ability to identify glycemic abnormalities in structured self-monitoring of blood glucose (SMBG) data and then make appropriate therapeutic changes based on the glycemic patterns observed. RESEARCH DESIGN AND METHODS In this prospective, randomized, controlled, multicenter study, 288 clinicians (39.6%...

BACKGROUND Patients with multidrug-resistant (MDR) tuberculosis may have phenotypic heterogeneity in results of drug-susceptibility tests (DSTs). However, the impact of this on clinical outcomes among patients treated for MDR tuberculosis is unknown. METHODS Phenotypic DST heterogeneity was defined as presence of at least 1 Mycobacterium tuberculosis isolate susceptible to rifampicin and ison...

BACKGROUND The purpose of this study was to compare the turnaround time for liquid culturing and primary anti-tuberculous drug susceptibility testing (DST) performed using the mycobacteria growth indicator tube (MGIT) 960 system (Becton Dickinson, USA) with that for conventional culturing and DST (by the absolute concentration method) performed using solid culture medium and to determine the co...

The concept of sectorization of the transformed images for CBIR is an innovative idea. This paper introduces the concept of Wavelet generation for Discrete sine transform (DST).The sectorization of the DST transformed images and the DST wavelet transforms has been done into various sector sizes i.e.4,8,12, and 16. The transformation of the images is tried and tested threefold i.e. row wise tran...

Donor-specific allograft tolerance can be induced in the adult rat by pregraft donor-specific blood transfusion (DST). This tolerance appeared to be mediated by regulatory cells and to the production of the suppressive cytokine TGF-beta1. A potential immunoregulatory CD8+ clone bearing a Vbeta18-Dbeta1-Jbeta2.7 TCR gene rearrangement was previously identified in DST-treated recipients. To asses...

INTRODUCTION Daylight saving time (DST), implemented as an energy saving policy, impacts many other aspects of life; one is road safety. Based on vehicle crash data in Minnesota from 2001 to 2007, this paper evaluates long- and short-term effects of DST on daily vehicle crashes. METHOD To provide evidence to explain the causes of more/fewer crashes in DST, we examine the impact of DST on cras...

A new motion estimation scheme, Discrete-Cosine/SineTransform Based Motion Estimation (DXT-ME) utilizing the principle of orthogonality of cosine and sine functions to estimate, in the transform domain, displacements from the motion information contained in the pseudo-phases of the images of moving objects, is proposed. The computational complexity of this method is only O ( N 2 ) + O d c t for...