The membrane-anchored heparin-binding EGF-like growth factor precursor (proHB-EGF)/diphtheria toxin receptor (DTR) belongs to a class of transmembrane growth factors and physically associates with CD9/DRAP27 which is also a transmembrane protein. To evaluate the biological activities of proHB-EGF/DTR as a juxtacrine growth factor and the biological significance of its association with CD9/DRAP2...

Two recombinant fragments of diphtheria toxin (DT) were fused to an engineered tandem repeat of the immunoglobulin (Ig) binding domain of protein A, called ZZ. These fragments are (i) the receptor binding domain (DTR), which comprises amino acids 382 to 535 of DT, and (ii) a linear peptide (DT(168-220)) which comprises residues 168 to 220 of the loop between fragment A and fragment B of DT. The...

Diurnal temperature range (DTR) is an important meteorological indicator associated with global climate change, and has been linked with mortality and morbidity in previous studies. To date, however, little evidence has been available regarding the association of DTR with years of life lost (YLL). This study aimed to evaluate the DTR-related burden on both YLL and mortality. We collected indivi...

Classical dendritic cells (cDCs), monocytes, and plasmacytoid DCs (pDCs) arise from a common bone marrow precursor (macrophage and DC progenitors [MDPs]) and express many of the same surface markers, including CD11c. We describe a previously uncharacterized zinc finger transcription factor, zDC (Zbtb46, Btbd4), which is specifically expressed by cDCs and committed cDC precursors but not by mono...

This study examines the relationship between diurnal temperature range (DTR) and land use/land cover (LULC) in a portion of the Southeast. Temperature data for all synoptically weak days within a 10-yr period are gathered from the National Climatic Data Center for 144 weather stations. Each station is classified as one of the following LULC types: urban, agriculture, evergreen forest, deciduous...

Dengue is a mosquito-borne viral disease that occurs mainly in the tropics and subtropics but has a high potential to spread to new areas. Dengue infections are climate sensitive, so it is important to better understand how changing climate factors affect the potential for geographic spread and future dengue epidemics. Vectorial capacity (VC) describes a vector's propensity to transmit dengue t...

Trends in the diurnal temperature range (DTR) are examined in the late twentieth and the twenty-first centuries in a coupled climate model representing the atmosphere, ocean, sea ice, and land surface systems. Consistent with past studies, the DTR decreases during this time. These decreases are concentrated in middle latitudes, with much smaller changes occurring in the low latitudes. Strong se...

The disrupt-then-reframe compliance gaining technique (DTR; Davis & Knowles, 1999) uses confusing language and then follows it with an additional reason to comply. The effectiveness of the DTR was meta-analyzed by calculating the weighted mean correlation coefficient (r1⁄4 .28) and the weighted mean odds ratio (OR1⁄4 3.47). Using the DTR in a sales context versus a nonprofit context was a moder...

Previous observational research has indicated the effectiveness of a 12-step, dual-focus mutual aid group, Double Trouble in Recovery (DTR), for assisting individuals to recover from co-occurring substance use and psychiatric disorders. The current study extends this line of research by evaluating DTR with a quasi-experimental design; controlled designs are rare in studies of mutual aid. Patien...

We propose a new mechanism that could contribute to The highly interactive nature of general circulation models the observed decrease in the diurnal temperature range (DTR) (GCMs) as well as weaknesses in their parameterizations make it over the last century: the physiological behavior of vegetation in difficult to identify the mechanisms underlying predicted changes response to climate. Using ...