The following articles are being highlighted as part of Circulation: Cardiovascular Imaging’s Topic Review. This series summarizes the most important articles, as selected by the editors, that have published in the Circulation portfolio. The studies included in this article represent the most significant research in the area of structural heart disease, cardiac function, aortic disease, and mol...

Peter Dayan E25-210, MIT Cambridge, MA 02139 We provide a model of the standard watermaze task, and of a more challenging task involving novel platform locations, in which rats exhibit one-trial learning after a few days of training. The model uses hippocampal place cells to support reinforcement learning, and also, in an integrated manner, to build and use allocentric coordinates.

The following articles are being highlighted as part of Circulation: Cardiovascular Imaging’s Topic Review. This series summarizes the most important articles, as selected by the editors, that have published in the Circulation portfolio. The studies included in this article represent the most significant research in the area of structural heart disease, cardiac function, aortic disease, and mol...

Heme-copper oxidases (HCuOs) are the last components of the respiratory chain in mitochondria and many bacteria. They catalyze O(2) reduction and couple it to the maintenance of a proton-motive force across the membrane in which they are embedded. In the mitochondrial-like, A family of HCuOs, there are two well established proton transfer pathways leading from the cytosol to the active site, th...

The development of the financial system is shown, both historically and in contemporary data, to be adversely affected by inequality in the distribution of land. To accommodate these empirical findings, a theory is developed that highlights the incentives of landowners to oppose competition in the financial sector. The theory provides an explanation for the co-incident development of the financ...

Sayan Mukherjee CBCL, MIT E25-201 Cambridge, MA 02142 [email protected] A new method for multivariate density estimation is developed based on the Support Vector Method (SVM) solution of inverse ill-posed problems. The solution has the form of a mixture of densities. This method with Gaussian kernels compared favorably to both Parzen's method and the Gaussian Mixture Model method. For synthetic ...

Enerji ihtiyacını karşılamak için ülkemizde olduğu gibi dünya genelinde de hâlihazırda petrol türevli yakıtlar kullanılmaktadır. Artan sanayileşme ve nüfus yoğunluğu buna bağlı olarak taşıt miktarı ile birlikte petrole olan eğilim daha da artmakta, bu durum kaynakların tükenmesine yol açmaktadır. Petrol rezervlerinin gün geçtikçe azalması petrolün çevreye olumsuz etkileri göz önüne alındığında ...

Omalizumab (anti-IgE ab) is a recombinant humanized monoclonal antibody (rhuMAb-E25) developed by immunizing mice with human IgE. Then, a monoclonal antibody was selected that recognizes IgE at the same site as the highaffinity receptor for IgE (FcεRI). Omalizumab is the only Mab to date that has been found to be effective and approved by both the FDA and European Medicines Agency (EMA) for the...

Disorders of the maternal-placental-fetal unit often results in fetal brain injury, which in turn results in one of the highest burdens of disease, because of the lifelong consequences and cost to society. Investigating hypoxia-ischemia in the perinatal period requires the factoring of timing of the insult, determination of end-points, taking into account the innate development, plasticity, and...