BACKGROUND The lung expresses large amounts of endothelin-converting enzyme-1 (ECE-1), which catalyzes a step in the biosynthesis of potent vasoactive endothelin-1 (ET-1) from the inactive intermediate big ET-1. Because there has been no report concerning a possible relationship between ET-1 and ECE-1, we investigated the effects of ET-1 on ECE-1 expression in cultured rat pulmonary endothelial...

AIM To evaluate the role of preoperative multi-parametric magnetic resonance imaging (MP-MRI) in patients undergoing radical prostatectomy. Specifically, the accuracy of MP-MRI in detecting extracapsular extension (ECE) and individuating the side of the index lesion have been explored. METHODS Thirty-five consecutive patients undergoing radical prostatectomy have been retrospectively analyzed...

The distribution of endothelin-converting enzyme-1 (ECE-1) mRNA and protein was investigated in human kidney excised because of renal tumors. ECE-1 immunoreactivity was detected by immunohistochemistry throughout the different areas of the kidney in the vascular and tubular structures. In the cortex, ECE-1 immunostaining was present in the endothelial surface of arcuate and interlobular arterie...

In this paper, the typical electrical and computer engineering (ECE) curriculum is examined to determine its effectiveness at presenting embedded programming skills. The software concepts and programming techniques necessary for embedded systems are somewhat different than those seen in other engineering domains. Thus, it makes sense to specifically address embedded programming needs within the...

At the EC-19 workshop there were ten presentations in the topic of diagnosing and heating plasmas with Electron Cyclotron Emission (ECE) and Electron Bernstein Wave (EBW). Innovations continue in designs of ECE systems while tried-and-true instruments still provide adequate data to explore new areas of research. Heterodyne radiometers and Michelson interferometers carry on as the bedrock of ECE...

Speakers: Aditya Gopalan (ECE, IISc Bengaluru) Ketan Rajawat (EE, IIT Kanpur) Amitabha Bagchi (CSE, IIT Delhi) Krishna Jagannathan (EE, IIT Madras) Anand Louis (CSA, IISc Bengaluru) Nikhil Karamchandani (EE, IIT Bombay) Avhishek Chatterjee (EE, IIT Madras) Piyush Srivastava (STCS, TIFR) Bruce Hajek (ECE, UIUC) Praneeth Netrapalli (MSR Bengaluru) Chandra Murthy (ECE, IISc Bengaluru) Rajesh Sunda...

INTRODUCTION Preoperative parameters for predicting extraprostatic extension (ECE) in clinically organ-confined prostate cancer patients are not well defined. Our aim was to evaluate the roles of the biopsy Gleason score, prostate-specific antigen (PSA)-based parameters, volume, and clinical T classification in prediction of ECE. MATERIALS AND METHODS A total of 188 patients with clinically o...

Neutral endopeptidase-24.11 (neprilysin; NEP/CD10) is a cell surface metallopeptidase expressed by prostatic epithelial cells that degrades various bioactive peptides including endothelin. Endothelin-converting enzyme (ECE), the key enzyme of endothelin biosynthesis, catalyses the final processing step in the pathway. Neuropeptide substrates of NEP, including endothelin, have been implicated in...

Doxorubicin is an effective antineoplastic drug; however, its clinical benefit is limited by its cardiotoxicity. The inhibition of mitochondrial biogenesis is responsible for the pathogenesis of doxorubicin-induced cardiomyopathy. Endothelin-1 is a vasoconstrictive peptide produced from big endothelin-1 by endothelin-converting enzyme-1 (ECE-1) and a multifunctional peptide. Although plasma end...

Doxorubicin is an effective antineoplastic drug; however, its clinical benefit is limited by its cardiotoxicity. The inhibition of mitochondrial biogenesis is responsible for the pathogenesis of doxorubicin-induced cardiomyopathy. Endothelin-1 is a vasoconstrictive peptide produced from big endothelin-1 by endothelin-converting enzyme-1 (ECE-1) and a multifunctional peptide. Although plasma end...