Echinops echinatus Linn. (Fam. Asteraceae) possesses medicinal value a good deal. The plant is nerve tonic that stimulates liver and increases appetite, effective as anti-inflammatory in jaundice. Objective of the current study was to standardize (E. echinatus), both macroscopically microscopically. Pharmacognostic standardization with help different physicochemical parameters fluorescence anal...

Echinopines A (1) and B (2), novel sesquiterpenoids with an unprecedented rearranged skeleton named echinopane, were isolated from the roots of Echinops spinosus. The structures were elucidated by extensive spectroscopic analysis. The relative configuration of 1 was assigned by a combination of NOESY correlations and a simulation analysis. A plausible biosynthetic pathway for echinopane was dis...

BACKGROUND The emergence of multi-drug resistant (MDR) phenotypes is a major public health problem today in the treatment of bacterial infections. The present study was designed to evaluate the antibacterial activities of the methanol extracts of eleven Cameroonian spices on a panel of twenty nine Gram negative bacteria including MDR strains. METHODS The phytochemical analysis of the extracts...

Malaria is one of the world's most severe endemic diseases and due to the emergence of resistance to the currently available medicines, the need for new targets and relevant antimalarial drugs remains acute. The crude extract, four solvent fractions and two isolated compounds from the roots of Echinops hoehnelii were tested for their antimalarial activity using the standard four-day suppressive...

Echinops spinosus, belonging to Asteraceae family, is used in folk medicine as an abortifacient and diuretic for blood circulation, diabetes, stomach pain, indigestion spasmolytic problems. The objective of this work the study acute toxicity, content phenolic compounds (polyphenols, flavonoids tannins), antioxidant activity (DPPH, ABTS, FRAP, H2O2 xanthine oxidase) antidiabetic (?-amylase, ?- g...

A natural alkynol group-substituted thiophene, 2-(penta-1,3-diynyl)-5-(3,4-dihydroxybut-1-ynyl)-thiophene (PDDYT), was isolated from the roots of Echinops grijsii Hance. It possessed potent NAD(P)H: quinone oxidoreductase1 (NQO1) inducing activity and could activate Keap1-Nrf2 pathway effectively in murine hepatoma Hepa 1c1c7 cells. Further investigations indicated that the activation of Keap1-...

from flora of north west of iran, four contrasting species in term of frequency and coverage on heavy metal rich soils were selected to study physiological mechanisms for different tolerance of zn and cu toxicity in a hydroponic culture experiment. for study of zn toxicity, dactylis glomerata and secale monatum and for cu, cichorium intybus and astragalus echinops were selected. a clear differe...