RNA editing by ADARs can change the coding potential of protein-coding mRNAs. So far, this type of RNA editing has mainly been shown to affect RNAs expressed in the nervous system with much lower editing levels being observed in other tissues. The actin crosslinking proteins filamin α and filamin β are widely expressed in most tissues. The mRNAs encoding either protein are edited at the same po...

The need for manual editing during construction of a treebank may impose constraints on the representation of dependency trees which are not optimal for linguistic exploration. Using XML-technology it is possible to maintain the treebank both in a form suitable for editing and in a form suitable for linguistic exploration. By choosing a compact representation, we can use XPath directly as query...

The serotonin 2C receptor (5-HT2CR) is widely distributed in the central nervous system and participates in a variety of brain functions and mental diseases such as depression.1 The 5-HT2CR mRNA, as well as genes encoding receptors such as the AMPA type glutamate receptor,2 the potassium channel KCNA13 and GABAA receptor subunit α34 undergoes adenosine-to-inosine RNA editing5 mediated by adenos...

We developed a multiplex single-base extension single-nucleotide polymorphism-typing procedure for screening large numbers of plants for mutations in mitochondrial RNA editing. The high sensitivity of the approach detects changes in the RNA editing status generated in total cellular cDNA from pooled RNA preparations of up to 50 green plants. The method has been employed to tag several nuclear e...

Adenosine-to-inosine (A-to-I) editing of RNA transcripts is an increasingly recognized cellular strategy to modulate the function of proteins involved in neuronal excitability. We have characterized the editing of transcripts encoding the alpha3 subunit of heteromeric GABA(A) receptors (Gabra3), in which a genomically encoded isoleucine codon (ATA) is converted to a methionine codon (ATI) in a ...

RNA editing is a term describing a variety of novel mechanisms for the modification of nucleotide sequences of RNA transcripts in different organisms. These editing events include (a) the U-insertion and -deletion type of editing found in the mitochondrion of kinetoplastid protozoa, (b) the C-insertion editing found in the mitochondrion of Physarum, (c) the C-to-U substitution editing of the ma...

Post-transcriptional editing of pre-mRNAs through the action of dsRNA adenosine deaminases results in the modification of particular adenosine (A) residues to inosine (I), which can alter the coding potential of the modified transcripts. We describe here three sites in the para transcript, which encodes the major voltage-activated Na(+) channel polypeptide in Drosophila, where RNA editing occur...

In two inbred strains of mice, C57BL/6 and 129Sv, the majority of forebrain neocortical pre-mRNA encoding the serotonin 2C (5-HT2C) receptor is altered by adenosine-to-inosine editing. As a result, >60% of all mRNAs encode receptors with reduced constitutive and agonist-stimulated activity. However, in the BALB/c strain, a genetically distinct inbred strain with lower forebrain serotonin levels...

in present research, four of qajar prose works were initially selected as following: nasekh al-tavarikh of muhammad taghi lesan al-molk sepehr, masalek al-mohsenin of ‘abd al-rahim tabrizi, majma’ al-fosaha of reza gholi khan hedayat, and hezar-o-yek shab translated by ‘abd al-latif tasuji tabrizi. their most important writing and editing errors such as verbs, plural signs, words and structures...