Neuroblastoma is a biologically and clinically heterogeneous pediatric malignancy that includes a high-risk subset for which new therapeutic agents are urgently required. As well as MYCN amplification, activating point mutations of ALK and NRAS are associated with high-risk and relapsing neuroblastoma. As both ALK and RAS signal through the MEK/ERK pathway, we sought to evaluate two previously ...

This text was originally published as an article in Semiotica 66-1/3 (1987), pp. 279-298. Copyright P Tagg (author, Liverpool) and Mouton de Gruyter (publishers, Amsterdam). This text is basically the same as that sent unedited to Mouton de Gruyter in 1986, except that bibliographical references have been corrected. Footnote numbers are not the same as in the Semiotica version. Starts of pages ...

deformation pattern of the northeastern part of the iranian-arabian collision zone (i.e., mainly sanandaj-sirjan belt or zone) is the main concern of this paper. here, we investigate the stress distribution and displacement pattern of eghlid-deh bid area as affected by the position of zagros suture using a three dimensional mechanical model. the modeled area is located between the zagros thrust...

We report the results of parsec-scale, multi-frequency VLBA observations of the core region of 3C 279 in Stokes I, linear polarization, and circular polarization. These full polarization spectra are modeled by radiative transfer simulations to constrain the magnetic field and particle properties of the parsec-scale jet in 3C 279. We find that the polarization properties of the core region, incl...

This is a (moderately long) book-length discussion of a problem that exercised the fathers of Analytic Philosophy, following a distinguished tradition in fact traceable to Plato’s later dialogues, the Parmenides and the Sophist. It is a problem that is not often discussed these days (but see King 2007, whose views are not explicitly discussed in this book – curiously, for a work otherwise as sc...

Ewing sarcoma is an aggressive tumor of bone and soft tissue affecting predominantly children and young adults. Tumor-specific chromosomal translocations create EWS-FLI1 and similar aberrant ETS fusion proteins that drive sarcoma development in patients. ETS family fusion proteins and over-expressed ETS proteins are also found in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (AL...

CO(2) sensation represents an interesting example of nervous system and behavioral evolutionary divergence. The underlying molecular mechanisms, however, are not understood. Loss of microRNA-279 in Drosophila melanogaster leads to the formation of a CO(2) sensory system partly similar to the one of mosquitoes. Here, we show that a novel allele of the pleiotropic transcription factor Prospero re...

and Clinical Immunology Unit, Antalya Education and Training Hospital, Antalya, Turkey; Division of Cellular & Molecular Biology, Toronto Hospital, University Health Network, Toronto, ON, Canada; Department of Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Turkey; Oncology Unit, Denizli Education and Training Hospital, Denizli, Turkey; Human Gene and Cell Therapy Center of Akde...

We have analyzed the presentation of human histocompatability leukocyte antigen-A*0201-associated tumor peptide antigen MAGE-3271-279 by melanoma cells. We show that specific cytotoxic T lymphocyte (CTL)-recognizing cells transfected with a minigene encoding the preprocessed fragment MAGE-3271-279 failed to recognize cells expressing the full length MAGE-3 protein. Digestion of synthetic peptid...