The standard mathematical model for stepwise "slow-binding" enzyme inhibition (E+Iright harpoon over left harpoonEIright harpoon over left harpoonEI( *)) assumes that the initial enzyme-inhibitor complex EI is always at equilibrium with the free component species E and I. This assumption implies that the dissociation rate constant (EI-->E+I) is infinitely higher than the isomerization rate cons...

Enzyme I (EI), the first component of the bacterial phosphotransfer signal transduction system, undergoes one of the largest substrate-induced interdomain rearrangements documented to date. Here we characterize the perturbations generated by two small molecules, the natural substrate phosphoenolpyruvate and the inhibitor α-ketoglutarate, on the structure and dynamics of EI using NMR, small-angl...

An ecological interface (EI) consists in a user interface (UI) displaying the constraints of a specific environment in order to support a user’s decision-making process. The design gap problem can be decomposed in three broad categories: incomplete process description, confusing and lacking representations, lack of integration with a software internal structure. In order to address these proble...

MCF-7 cells display both nitrobenzylthioinosine (NBMPR)-sensitive (es) and NBMPR-insensitive (ei) equilibrative, but not the Na+-dependent, nucleoside transport. Transport of uridine by es is more sensitive to inhibition by purine nucleosides, whereas the ei component is more sensitive to nucleosides without an amino side group, such as inosine and thymidine. When exposed to 10 microM tamoxifen...

Stochastic behavior of stock returns is very important for investors and policy makers in the stock market. In this paper, the stochastic behavior of the return index of Tehran Stock Exchange (TEDPIX) is examined using unobserved component Markov switching model (UC-MS) for the 3/27/2010 until 8/3/2015 period. In this model, stock returns are decomposed into two components; a permanent componen...

The relationship between emotional intelligence (EI) and emotion information processing (EI P ) has received surprisingly little attention in the literature. present research addresses these gaps literature by introducing a conceptualization of as composed two distinct components: (1) EI K or Knowledge component, captured current ability tests, related to top-down, higher order reasoning about ...

We determine analytically the condition number of the PageRank problem. Specifically, we prove the following statement: “Let P be an n × n row-stochastic matrix whose diagonal elements Pii = 0. Let c be a real number such that 0 ≤ c < 1. Let E be the n × n rank-one row-stochastic matrix E = ev , where e is the n-vector whose elements are all ei = 1, and v is an n-vector that represents a probab...

It has been shown previously that background synaptic noise modulates the response gain of neocortical neurons. However, the role of the statistical properties of the noise in modulating firing rate is not known. Here, the dependence of firing rate on the statistical properties of the excitatory to inhibitory balance (EI) in cortical pyramidal neurons was studied. Excitatory glutamatergic and i...

The objective of this research is to identify the effects creative process (CP) in Create-EMO module on students’ emotional intelligence (EI) teaching and learning KOMSAS drama, an arts literature component Malay Language subject Malaysian secondary school. Teaching activities were based proposed by (Wallas, 1926). Students’ EI level was identified Goleman's (1995) four components EI: self-awar...