cardiovascular disease (cvd) is the leading cause of death and disability in developed countries. atherosclerosis is the major cause of cvd, accounting for about half of the attributed deaths. cholesterol homeostasis is one of the most important factors in atherosclerosis. atp-binding cassette transporters cholesterol. omega (ω) 3 fatty acids are important ligands for regulation of abc transpor...

The regulation of apolipoprotein B (apo B) metabolism by eicosapentaenoic acid was investigated in CaCo-2 cells. Cells cultured on semipermeable membranes that separated an upper from a lower well were incubated for 48 hours with albumin alone or 1 mM eicosapentaenoic acid or oleic acid attached to albumin (4:1, mol/mol). Compared with cells incubated with oleic acid, cells incubated with eicos...

background: diabetes mellitus is associated with chronic changes in peripheral arteries because of oxidative stress and insufficient antioxidative defense mechanism. omega-3 fatty acid supplementation could be effective in some diabetes complications; however, polyunsaturated fatty acids may increase lipid peroxidation. this study aimed to determine whether eicosapentaenoic acid alone or in con...

conclusions this report is the first to document other treatment possibilities for pressure ulcer and/or stasis dermatitis in cases where the use of topical applied ointments and medications is difficult. this new therapy may therefore help physicians to treat pressure ulcers and stasis dermatitis. case presentation case 1: a 21-year-old japanese female with lower-body paralysis. pressure ulcer...

a growing number of observational and epidemiological studies have suggested that mental illness, in particular mood disorders, is associated with decreased dietary intake and/or cellular abundance of omega-3 polyunsaturated fatty acids (pufa). this has prompted researchers to test the efficacy of omega-3 pufa in a range of different psychiatric disorders. we have critically reviewed the double...

objective: type 2 diabetes mellitus (dm-2) is a chronic and progressive metabolic disorder known as a serious threatening condition in the individual and society. type 2 diabetes mellitus is known as the major cause of cardiovascular diseases (cvd). contradictory evidences about the effect of omega-3 fatty acids on cvd risk factors, particularly hypertension. the aim of this study was to determ...

63 Received July 12, 2013; revised and accepted September 3, 2013. Published online September 25, 2013; doi: 10.1620/tjem.231.63. Correspondence: Susumu Ogawa, M.D., Ph.D., Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, 1-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan. e-mail: [email protected] Eicosapentaenoic Acid Improves Glycemic C...

Eicosapentaenoic acid prevents platelet aggregation and inhibits arachidonate conversion into thromboxane A2 and prostaglandins. Consequently eicosapentaenoic acid might protect the brain from the ischemia that follows cerebral arterial occlusion. We studied the effect of eicosapentaenoic acid on cerebral ischemia in anesthetized gerbils. Ischemia was produced by bilateral carotid occlusion for...

BACKGROUND The purpose of the study was to investigate effects of ethyl eicosapentaenoic acid on pharmacokinetics of metformin. Pharmacokinetic profiles of metformin and ethyl eicosapentaenoic acid when delivered separately or together in solid dose form were investigated and compared to determine whether the solid dose resulted in an altered metforminpharmacokinetics when given with or without...

Omega 3 fatty acids have healthcare benefits, but their absorption characteristics are not well defined, particularly for strategies to improve their bioavailability. We performed a double blind study comparing the bioavailability of 20% eicosapentaenoic acid in 4.5 grams of: natural triglyceride, reconstituted triglyceride, enzymatically synthesized triglyceride, monoglyceride and diglyceride....