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By ELIZABETH L. KNAPP, PH.D., AND JOSEPH I. ROUTH, PH.D. Iowa City, Iowa E LECTROPHORETIC analysis has been widely used in recent years as a method of study of the various components of the plasma proteins. The method has proved to be a valuable tool in the study of a great many diseases in which marked deviations from the normal electrophoretic pattern of plasma occur. For evaluation of the ch...

Abnormal electrophoretic pattern of serum lactate dehydrogenase isoenzyme is shown. In this case electrophoretic pattern showed a sharp single band between lactate dehydrogenase 4 and lactate dehydrogenase 5 and broad band between lactate dehydrogenase 2 and lactate dehydrogenase 4. This abnormality was suggested to be caused by the presence of lactate dehydrogenase and immunoglobulin G (kappa ...

We describe five cases of severe a1-antitrypsin (AAT) deficiency to illustrate the importance of visual inspection of electrophoretic patterns of serum proteins. In four patients the diagnosis of AAT deficiency was clinically unsuspected; in the other patient, the electrophoretic pattern was the first clue to confirm the diagnosis. Densitometric scanning of these patterns invariably overestimat...