High-stakes decisions for the instruction and assessment of English language learner (ELL) students are made based on the premise that ELL classification is a valid dichotomy that distinguishes between those who are proficient in the use of the English language and those who are not. However, recent research findings draw a vague picture of the term “ELL” and call for a more valid classificatio...

In this paper we define and explore the analytic spread ℓ ( I ) $\ell (\mathcal {I})$ of a filtration in local ring. We show that, especially for divisorial symbolic filtrations, some basic properties an ideal extend to even when is non-Noetherian. also illustrate significant differences between with examples. case $I$ , have classical bounds ht ⩽ dim R $\mbox{ht}(I)\leqslant \ell (I)\leqslant ...

In the `-Component Order Connectivity problem (` ∈ N), we are given a graph G on n vertices, m edges and a non-negative integer k and asks whether there exists a set of vertices S ⊆ V (G) such that |S| ≤ k and the size of the largest connected component in G−S is at most `. In this paper, we give a kernel for `-Component Order Connectivity with at most 2`k vertices that takes nO(`) time for eve...

BACKGROUND Osteoclasts are the only cell type capable of breaking down bone matrix, and its excessive activation is responsible for the development of bone-destructive diseases. Euphorbia lathyris L. (ELL) is an herbal plant that belongs to the Euphorbiaceae family. This study investigated the effects of the methanol extract of the aerial part of ELL on receptor activator of nuclear factor-kapp...

BACKGROUND Cardiac fibrosis is considered to be a crucial factor in the development of heart failure. Blockade of the mineralocorticoid receptor (MR) attenuated cardiac fibrosis and improved the prognosis of patients with chronic heart failure but the ligand for MR and the regulatory mechanism of MR pathway in the diseased heart are unclear. Here, we investigated whether glucocorticoids can pro...

Many sensory regions integrate information ascending from peripheral receptors with descending inputs from other central structures. However, the significance of these descending inputs remains poorly understood. Descending inputs are prominent in the electrosensory system of mormyrid fish and include both recurrent connections from higher to lower stages of electrosensory processing and electr...

To perform the jamming avoidance response (JAR), the weakly electric fish Gymnarchus detects time disparities on the order of microseconds between electrosensory signals received by electroreceptors in different parts of the body surface. This paper describes time-disparity thresholds of output neurons of the electrosensory lateral line lobe (ELL), where the representation of timing information...

Type-1 immunity plays a crucial role in host defense against various tumors and infectious diseases. Here, we first demonstrated that extract of Larix Leptolepis (ELL), one of the most popular timbers at Hokkaido area in Japan, strongly activated Type-1 immunity. ELL induced production of Type-1 cytokines such as IL-12 and TNF-α from bone marrow-derived dendritic cells (BMDCs) in TLR2- and TLR4...