Self-assessment and peer-assessment have been appraised in a large number of studies, aiming at investigating their effectiveness in different contexts. However, the challenges of implementing self-assessment and peer-assessment have been investigated rather sporadically. Given that, the purpose of this study was to explore the challenges and probable solutions of implementing self-assessment a...

A SAGE library was prepared from hand-dissected intestines from adult Caenorhabditis elegans, allowing the identification of >4000 intestinally-expressed genes; this gene inventory provides fundamental information for understanding intestine function, structure and development. Intestinally-expressed genes fall into two broad classes: widely-expressed "housekeeping" genes and genes that are eit...

Eltrombopag (ELT), an orally available thrombopoietin receptor agonist, is a substrate of organic anion transporting polypeptide 1B1 (OATP1B1), and coadministration of ELT increases the plasma concentration of rosuvastatin in humans. Since the pharmacokinetic mechanism(s) of the interaction is unknown, the present study aimed to clarify the drug interaction potential of ELT at transporters. The...

The main purpose of this article is to analyze the ELT scenario of community based schools in Surkhet district. This paper, presents an introduction of ELT curriculum of English in school level, current status of ELT achievement in Surkhet district, issues, challenges and problems overwhelmed around ELT in community-based schools, strategies to enhance the competence and performance of teachers...

GATA transcription factors play important roles in directing developmental genetic programs and cell differentiation, and are conserved in animals, plants and fungi. C. elegans has 11 GATA-type transcription factors that orchestrate development of the gut, epidermis and vulva. However, the expression of certain GATA proteins persists into adulthood, where their function is less understood. Accu...

Erlotinib (ELT), a tyrosine kinase inhibitor, is widely used for the treatment of nonsmall cell lung cancer in clinic. Unfortunately, severe drug-induced liver injury and other adverse effects occurred during the treatment. Meanwhile, ELT has been reported to be a mechanism-based inactivator of cytochrome P450(CYPs) 3A4 and 3A5. The objectives of this study were to identify ketene intermediate ...

Postembryonic development in Caenorhabditis elegans is a powerful model for the study of the temporal regulation of development and for the roles of microRNAs in controlling gene expression. Stable switch-like changes in gene expression occur during development as stage-specific microRNAs are expressed and subsequently down-regulate other stage-specific factors, driving developmental progressio...

In this paper, a new formulation based on Artificial Neural Networks (ANN) is presented for backcalculation of pavement layer moduli. In structural analysis of flexible pavements, the procedures as Layered Elastic Theory, Equivalent Layer Thickness (ELT), and Finite Elements Method (FEM) generally have complex formulations and give approximate results. Therefore, it is extremely difficult to pe...

Initially it was believed that when ELT-2 was knocked out in nematodes this caused the nematodes to become sick from all pathogens, even ones that were not previously pathogenic. However, an experiment conducted later suggested that in older cultures of bacteria the ELT-2 knocked out nematodes do not become sick from pathogens that were previously nonpathogenic. In order to clarify the role of ...