Background: Recurrent pregnancy loss (RPL) is a common and distressing disorder. RPL is a devastating reproductive problem affecting approximately 5% of couples trying to conceive. If we camper the rate of miscarriage in couples may experience RPL with the pregnancy loss rate in general population we may calculate that it is at least two or three times higher than expected. This study aimed to ...

Abstract Study question What is the degree of concordance between Noninvasive Preimplantation Genetic Testing for Aneuploidies (NIPGT-A) versus genetic analysis whole embryo? Summary answer Cell free DNA ploidy evaluated by NIPGT-A presents very good that from embryo cells (Cohen's Kappa coefficient: 0.84). known already After many years using PGT-A, there are still concerns, such as risks inva...

Background: The cause of fertilization failure in IVF is most often due to the absence of sperm penetration but the reason why fertilization does not occur when intracytoplasmic sperm injection (ICSI) is applied is not clear. However some intrinsic oocyte problems may also be responsible for fertilization failure. It has been reported that 13% of unfertilized oocytes after IVF show morphologica...

Background: Failed fertilization after intracytoplasmic sperm injection (ICSI) can be due to a reduced oocyte-activation capacity caused by reduced concentrations and abnormal localization of the oocyte-activation factor phospholipase C (PLC) zeta. Patients with this condition can be helped to conceive by artificial activation of oocytes after ICSI with calcium ionophore (assisted oocyte activa...

This study investigated the association between sediment contamination, PCB accumulation in adult nesting males and occurrence of embryonic abnormalities damselfish, Abudefduf sordidus, from two sites with high contamination three “reference” (contaminants very low or not measurable) within Johnston Atoll, Central Pacific Ocean. Developmental were assessed damselfish embryos collected field dur...