The current study was performed to analyse the potential existence and structure of a GHRH-transporting tuberoinfundibular system in the rat median eminence. The immunocytochemical analysis using anti-GHRH revealed an intense immunoreaction in the ependimary cells, tanycytes, at the level of the floor of the infundibular recess forming part of the median eminence. The basal processes of these c...

The participation of a growth hormone (GH) inhibitory noradrenergic input to the median eminence in stress-induced suppression of rat GH secretion was investigated in animals with median eminence catecholamine lesions produced by intravenous injection of 6-hydroxydopamine (6-OHDA). Unstressed lesioned rats exhibited an enhanced frequency of GH secretory bursts, but both intact and lesioned rats...

A full independent drug development programme to demonstrate efficacy may not be ethical and/or feasible in small populations such as paediatric populations or orphan indications. Different levels of extrapolation from a larger population to smaller target populations are widely used for supporting decisions in this situation. There are guidance documents in drug regulation, where a weakening o...

Giedrë Kobs1, Olaf Bernhardt2, Georg Meyer2 1 Department of Prosthetic Dentistry, Institute of Stomatology, Vilnius University, Vilnius, Lithuania 2 Department of Restorative Dentistry, Periodontology and Pediatric Dentistry, School of Dentistry, University of Greifswald, Germany The purpose of our research was to verify the hypothesis that flat articular eminence is the result of progressive i...

Adrenocorticotropin binding sites in the rat median eminence have been localized in vivo. These binding sites occur in the basalar zone, which is rich in axonal endings. Using competitive binding and quantitative light-microscope radioautography, we found that the median-eminence binding site, in contradistinction to the adrenal receptor, binds specifically the residue 4-10 region of the adreno...

BACKGROUND Fractures of the tibial intercondylar eminence are observed mostly in children and adolescents, often after minimal trauma. The purpose of this paper is to evaluate the use of K-wire fixation for the arthroscopic treatment of tibial eminence fractures in children. PATIENTS AND METHODS From January 2002 through January 2009 ten patients were treated arthroscopically because of the i...

Tibial eminence fracture, a bony avulsion of the anterior cruciate ligament (ACL) from its insertion on the intercondylar eminence, was first described by Poncet in 1875. Also known as tibial spine fractures, these injuries occur most commonly in skeletally immature patients between the ages of 8 and 14 years. They account for 2% to 5% of knee injuries in the pediatric population and 14% of ACL...