Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. They are made from polymeric waxy or other protective materials such as natural, semi synthetic and synthetic polymers. Microspheres are characteristically free flowing po...

The success in the preparation of Eudragit RS100 microspheres in 0.IN HCI solution using gelatin as antiaggregating agent, encouraged the selection of an acidic drug to be encapsulated using a solvent evaporation technique [1]. Ibuprofen is a non-steroidal, anti-inflammatory, analgesic and antipyretic drug approved for use as adjunct therapy in the treatment of rheumatoid and osteoarthritis [2]...

In this work, we are motivated by the need to produce particles of well-controlled size, shape and morphology for general application in catalysis, environmental remediation, nanomedicine, pharmaceuticals, the development of new materials, and other fields. Moreover, our approaches are guided by the desire for continuous and scalable production, in contrast to the batch-wise processes typically...

PURPOSE Sumatriptan succinate (Sum) is a Serotonin 5- HT1 receptor agonist, used in the treatment of migraine. It is absorbed rapidly but incompletely when taken orally and underwent first - pass metabolism, resulting in a low bioavailability of about 15%. The aim was to design mucoadhesive buccal discs and sublingual films of Sum and metoclopramide (Met) combined to improve their bioavailabili...

Abstract: Aim/Background: The purpose of the study was to fabricate and evaluate atenolol loaded micro-sponge in-situ gel. Materials Methods: Oil in Emulsion Solvent Diffusion Technique used for formulation microsponges by using different levels polymers such as Eudragit RS-100 Ethyl Cellulose. prepared micro-sponges were evaluated optical microscopy, percentage yield, drug content, entrapment ...

Eutectic solvent can solubilize high amount of some therapeutic compounds. Volatile eutectic solvent is interesting to be used as solvent in the preparation of nanosuspension with emulsion solvent evaporation technique. The mechanism of transformation from the eutectic emulsion to nanosuspension was investigated in this study. The 30% w/w ibuprofen eutectic solution was used as the internal pha...

Lysozyme was hydrophobically modified with a fatty acid, sodium oleate, via an ion-pairing mechanism. Ionic binding between an anionic carboxylic group of sodium oleate and basic amino groups in lysozyme was primarily utilized to form lysozyme-oleate complex. The complex formation was pH dependent. The lysozyme-oleate complex dissolved in an organic solvent exhibited much higher conformational ...

gallium extraction from jajarm bayer process liquor (jajarm, iran) was investigated using microemulsions. also the behavior of aluminum was studied as an impurity. kelex100 (4-ethyl, 1-methyl, 7-octyl, 8-hydroxyquinoleine), iso-decanol and n-butanol, and kerosene were used as the surfactant, co-surfactant, and oil phase, respectively. ternary phase diagrams were produced using various co-surfac...