نتایج جستجو برای: endocrine disruptor chemicals
تعداد نتایج: 87723 فیلتر نتایج به سال:
The hypothesis that hormonally active compounds in the environment—endocrine disrupters—are having a significant impact on human and ecological health has captured the public’s attention like no other toxicity concern since the publication of Rachel Carson’s Silent Spring (1962). In the early 1990s, Theo Colborn and others began to synthesize information about the potential impacts of endocrine...
The U.S. Environmental Protection Agency (EPA) is considering high-throughput and computational methods to evaluate the endocrine bioactivity of environmental chemicals. Here we describe a multistep, performance-based validation of new methods and demonstrate that these new tools are sufficiently robust to be used in the Endocrine Disruptor Screening Program (EDSP). Results from 18 estrogen rec...
Concern continues to grow over the negative impact of endocrine disrupting chemicals on environmental and public health. The number of identified endocrine disrupting chemicals is increasing, but biological endpoints, experimental design, and approaches for examining and assessing the impact of these chemicals are still debated. Although some workers consider endocrine disruption an "emerging s...
OBJECTIVE To study the effect of endocrine disruptor chemicals in cow milk on female reproductive system. METHODS A two-generation reproduction was conducted according to U. S. FDA standard. Milk was fed in special bottle to Wistar rats of both sexes through two successive generations (F0 and F1) in the milk group while artificial milk was fed to rats in the control group. Twenty-four rats of...
Endocrine Disrupting Chemicals (EDCs) or Disruptors are unique assemblage cluster of emerging pollutants as they affect the synthesis, release and transport hormones. EDCs have been associated with a diverse array health issues diseases. can alter endocrine system involved in carcinogenesis inducing poly-cystic ovary syndrome (PCOS). The objective this article is to furnish an outline research ...
The so called endocrine disruptors have become an important working hypothesis for a wide range of toxicology researchers. This hypothesis has also attracted those who have worked on designer estrogens or selective estrogen receptor modulators. Already numbers of substances have been identified as such chemicals, but there remain a large number of chemicals waiting to be tested for their endocr...
In 1996, the U.S. Congress passed the Food Quality Protection Act and amended the Safe Drinking Water Act (SDWA) requiring the U.S. Environmental Protection Agency (EPA) to implement a screening program to investigate the potential of pesticide chemicals and drinking water contaminants to adversely affect endocrine pathways. Consequently, the EPA launched the Endocrine Disruptor Screening Progr...
BACKGROUND The prioritization of chemicals for toxicity testing is a primary goal of the U.S. Environmental Protection Agency (EPA) ToxCast™ program. Phase I of ToxCast used a battery of 467 in vitro, high-throughput screening assays to assess 309 environmental chemicals. One important mode of action leading to toxicity is endocrine disruption, and the U.S. EPA's Endocrine Disruptor Screening P...
Environmental pollutants with hormonal activity, such as xenoestrogens, have for several years been of concern as potential risk factors for hormone dependant tumors. Impacts of increasing levels of xenoestrogens have been observed in aquatic organisms. In humans concern has been focused on ”endocrine disrupting chemicals” with either estrogenic or antiestrogenic activities. Some persistent org...
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