endothelial dysfunction which is manifested by the loss of nitric oxide bioavailability, is an increasingly recognized cause of cardiac syndrome x (csx) and beta blockers are used for the treatment of this syndrome. thus, the aim of this study was to investigate effects of metoprolol, as a beta blocker, on endothelial function in csx patients. the study included 25 csx patients (20 female/ 5 ma...

background: this study attempted to determine the effects of long-term use of vitamin c on vascular endothelial function. materials and methods: during a pilot clinical trial study conducted at imam hussein hospital (isfahan) in 2014-2015, a total of 40 diabetic patients were selected and then assigned randomly into two 20-subject groups receiving vitamin c and placebo tablets. the patients wer...

objective: endothelium is a selective and permeable membrane for transferring nutrients and vital components to arterial wall. endothelial damage might lead to altered biological function of endothelium and clinical consequences such as atherosclerosis. blood pressure pulse always exerts circumferential tension to the arterial wall. hence, such tension together with other loads, play important ...

objective: in this investigation murine embryonic stem (es) cells were differentiated into endothelial cells. materials and methods: murine es cells (cce cell line) exposed to alpha-mem medium containing 10% fbs for 4 days. then obtained flk-1 (flk-1: vascular endothelial growth factor receptor 2) positive cells were cultuted in endothelial growth medium-2 (egm-2) until the last day of experime...

Accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. NADPH oxidase has been recognized as a major source of oxidative stress in vasculature. However, the relation between NADPH oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. The present study aimed to investigate the rel...

purpose: to compare clinical and confocal scan outcomes after descemet stripping automated endothelial keratoplasty (dsaek) performed for fuchs’ endothelial dystrophy versus pseudophakic bullous keratopathy. methods: in this retrospective comparative study, 47 consecutive eyes of 39 patients with the diagnosis of fuchs’ endothelial dystrophy (n=29, group 1) or pseudophakic bullous keratopathy (...

introduction: endothelial progenitor colony forming unit-endothelial cells (cfu-ec) were first believed to be the progenitors of endothelial cells, named endothelial progenitor cells. further studies revealed that they are monocytes regulating vasculogenesis. the main hindrance of these cells for therapeutic purposes is their low frequency and limited replicative potentials. this study was unde...