As a member of the Immunophilin family, cyclophilin38 (CYP38) is discovered to be localized in the thylakoid lumen, and is reported to be a participant in the function regulation of thylakoid membrane protein. However, the molecule mechanisms remain unclear. We found that, CYP38 plays an important role in the process of regulating and protecting the plant to resist high light (HL) stress. Under...

SCOPE The impact of L-ascorbic acid (L-AA) on the chemokinesis (CK) and chemotaxis (CT) of HL-60 cells and polymorphonuclear cells (PMN) was investigated. METHODS AND RESULTS HL-60 cells were differentiated with DMSO, retinoic acid (RA), vitamin D, or L-AA. Chemokinesis and chemotaxis of differentiated HL-cells were assayed. Vitamin D3-treated HL-60 cells (dHL-60vitD3 cells) and RA-treated ce...

Curcumin is the main biologically active phytochemical compound in turmeric. It has been shown to have anticarcinogenic activity. The aims of the study were to identify the mechanism of apoptosis of HL-60 human promyelocytic leukemic cells induced by curcumin and to determine the effects of water-soluble antioxidants, ascorbic acid, Trolox (a water-soluble form of vitamin E), glutathione (GSH) ...

The human myeloid cell line HL-60 expresses approximately 300 high-affinity granulocyte-macrophage colony-stimulating factor receptors (GM-CSFRs), yet treatment of these cells with GM-CSF does not result in enhanced cellular proliferation or increases in protein tyrosine phosphorylation. In contrast, GM-CSF induces rapid increases in protein tyrosine phosphorylation and proliferative responses ...

GS-1101 (CAL-101) is an oral PI3K specific inhibitor that has shown preclinical and clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. To investigate the potential role of PI3K in Hodgkin lymphoma (HL), we screened 5 HL cell lines and primary samples from patients with HL for PI3K isoform expression and constitutive PI3K pathway activation. Inhibition of PI3K by GS-1101...

The scenario of multi-sector SUSY breaking predicts pseudo-goldstinos which are not absorbed by the gravitino and their mass can be as low ${{\cal O} (0.1)}$ GeV. Since interactions so weak gravitino, a produced higgsino decay to pseudo-goldstino plus Higgs boson insider detector at LHC, thus pair production lead signal missing energy. For natural requires rather light higgsinos, such events ma...

Background and aims: Health literacy (HL) can affect individual health, health communication anderror in taking medicine. The aim of this study was to determine the level of HL and associated factorsamong Iranian adults.Methods: In this cross-sectional study, 240 participants over 18 years of age referring to health centersin Hamadan, west of Iran in 2015 were selected b...

The HL-60 leukemia cell line derived from a human acute promyelocytic leukemia is stimulated to differentiate into macrophages within 24-28 hr after exposure to the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA). We studied early alterations (within 90 min of exposure to TPA) in phosphatidylcholine metabolism in HL-60 cells and found that phosphatidylcholine synthesis by methylation ...

Retinoic acid is known to cause the cell cycle arrest and myeloid differentiation of HL-60 myeloblastic leukemia cells. Evidence suggesting the possible involvement of the Fc RII immunoglobulin receptor in mediating retinoic acid-induced growth arrest and differentiation of HL-60 cells is presented. HL-60 cells stably transfected with the 205 mutant polyoma middle T antigen, a largely debilitat...