The prostanoid receptors on human airway smooth muscle cells (HASMC) that augment the release by IL-1beta of granulocyte colony-stimulating factor (G-CSF) have been characterized and the signaling pathway elucidated. PCR of HASM cDNA identified products corresponding to EP(2), EP(3), and EP(4) receptor subtypes. These findings were corroborated at the protein level by immunocytochemistry. IL-1b...

Parabens are widely used as preservative substances in foods, pharmaceuticals, industrial products, and cosmetics. But several studies have cautioned that parabens have estrogenic or endocrine-disrupting properties. Drosophila melanogaster is an ideal model in vivo to detect the toxic effects of chemistry. The study was designed to assess the potential additive toxic effects of methylparaben (M...

We define a new algebraic form for Boolean function representation, called EXOR-Projected Sum of Products (EP-SOP), consisting in a four level network that can be easily implemented in practice. Deriving an optimal EP-SOP from an optimal SOP form is a NP NP -hard problem; nevertheless we propose a very efficient approximation algorithm, which returns, in polynomial time, an EP-SOP form whose co...

Morbidity and mortality of the infected patients by multidrug-resistant bacteria have increased, emphasizing urgency fight for discovery new innovative antibiotics. In this sense, natural products emerge as valuable sources bioactive compounds. Among biodiversity, Eryngium pristis Cham. & Schltdl. (Apiaceae Lindl.) is traditionally used to treat thrush ulcers throat mouth, diuretic emmenago...

The dependence of the fractal behaviors of the pomeron induced system in deep inelastic lepton-nucleon scattering upon the diffractive kinematic variables is found not to sensitive to the distinct parameterization of the pomeron flux factor and the structure function. A feasible experimental test of the phenomenological pomeron model in DESY ep collider HERA is proposed.

A pharmacokinetics and metabolism study was conducted in eight healthy human volunteers. After oral administration of [14C]eplerenone (EP) at a dose of 100 mg per person as an aqueous solution, blood, saliva, breath, urine, and fecal samples were collected at various time points. All matrices were analyzed for total radioactivity and/or for EP and its open-lactone-ring form (EPA). EP was well a...

In the title compound, C(9)H(11)BrN(2)O(5), the ribofuran-ose ring has a C2-exo, C3-endo twist configuration and is attached to the uracil unit via a β-N(1)-glycosidic bond. The crystal structure is stabilized by two inter-molecular O-H⋯O inter-actions and one inter-molecular N-H⋯O inter-action.

Inhaltsverzeichnis Einleitung 2 1 Theoretische Grundlagen 4 1.1 Tief inelastische ep-Streuung und

The title compound, C(6)H(12)O(6), also known as d-Tagatose, occurs in its furanose and pyranose forms in solution, but only the α-pyran-ose form crystallizes out. In the crystal, the molecules form hydrogen bonded chains propagating in [100] linked by O-H⋯O interactions. Further O-H⋯O bonds cross-link the chains.

The title compound, C(19)H(26)O(8)S, has been synthesized from 2,3:4,5-di-O-isopropyl-idene-β-d-fructopyran-ose. The absolute configuration of the fused ring is confirmed by anomalous dispersion effects in the diffraction measurement. The six-membered β-fructopyran-ose ring has a twist-boat conformation with the two five-membered rings trans to each other. In the crystal, inter-molecular non-cl...