PURPOSE Eperisone Hydrochloride (EPE) is a potent new generation antispasmodic drug which is used in the treatment of moderate to severe pain in combination with Paracetamol (PAR). Both drugs are available in tablet dosage form in combination with a dose of 50 mg for EPE and 325 mg PAR respectively. METHODS The method is based upon Q-absorption ratio method for the simultaneous determination ...

The effects of various sodium channel blocking agents on acute thermal and mechanical nociception, as assessed using the plantar and tail pressure tests, respectively, were compared with the effects of morphine. The drugs used were mexiletine, lidocaine, carbamazepine, phenytoin, eperisone, tolperisone, and zonisamide. The sodium channel blocking agents exhibited a rather preferential elevation...

Abstract Muscle cramps appearing in liver cirrhosis substantially affect the quality of life these patients. The prevalence painful muscle can be up to 88%. exact mechanism by which occur is unknown. management this symptom not easy because there no uniformly accepted recommendation about what kind supplementation or medicine (or both) used exactly. aim our study review treatment options for ci...

BACKGROUND Trials on sling exercise (SE), commonly performed to manage chronic low back pain (LBP), yield conflicting results. This study aimed to review the effects of SE on chronic LBP. METHODS The randomized controlled trials comparing SE with other treatments or no treatment, published up to August 2013, were identified by electronic searches. Primary outcomes were pain, function, and ret...

spectrophotometric and electrochemical studies were successfully used in quantitative analysis of amitriptyline hydrochloride (ath) and nortriptyline hydrochloride (nth). conductometric titration were carried out in equeous solution using iodide and dopamine and serotonine as titrant. two new methods using spectrophotometry are dascribed for the determination of (ath) and (nth) with potassium b...