Subcutaneous treatment of 50% EtOH extract of neem bark (Azadirachta indica A. juss) to male rats at the dose of 10 mg for 30 days caused arrest of spermatogenesis. The diameter of serminiferous tubule, Leydig cell nucleus and epithelial heights of epididymides were significantly reduced (p≤0.001). Sperm motility and density were significantly reduced. Reduced testicular and accessory organ pro...

The cysteine rich prostate and testis expressed (Pate) proteins identified till date are thought to resemble the three fingered protein/urokinase-type plasminogen activator receptor proteins. In this study, for the first time, we report the identification, cloning and characterization of rat Pate gene cluster and also determine the expression pattern. The rat Pate genes are clustered on chromos...

Polyamines are known to play important roles in the proliferation and differentiation of many types of cells. Although considerable amounts of polyamines are synthesized and stored in the testes, their roles remain unknown. Ornithine decarboxylase antizymes (OAZs) control the intracellular concentration of polyamines in a feedback manner. OAZ1 and OAZ2 are expressed ubiquitously, whereas OAZ-t/...

The effects of a single dose to testosterone on the content of DNA, RNA and protein and the incorporation of [3H]phenylalanine into protein in the epididymis, vas deferens and ventral prostate of the rat were studied. A single dose of testosterone did not increase the weights of the accessory organs but restored the incorporation of [3H]phenylalanine into proteins in the catput, corpus and caud...

BACKGROUND Pyridaben, a pyridazinone derivative, is a new acaricide and insecticide for control of mites and some insects such as white flies, aphids and thrips. OBJECTIVE This study was designed to elucidate how pyridaben can affect the sperms' morphological parameters, its DNA integrity, and to estimate the effect of various quantities of pyridaben on in vitro fertilization rate. MATERIAL...

The present study was undertaken to clarify changes in secretions of FSH, LH, inhibin and testosterone, and sperm motility after bilateral vasectomy in adult male rats. Bilateral vasectomy was created surgically (treated group) and intact rats were used as control (control group). On days 3, 5, 7, 14, 30, 60, and 90 after surgery, plasma concentrations of FSH, LH, inhibin, and testosterone were...

BACKGROUND Localized amyloidosis has not been documented in the epididymis; we report this phenomenon for the first time. CASE PRESENTATION The first aim of this work is to report three cases of localized epididymal amyloidosis. Two cases were clinically detected as epididymal nodules, and a third after reviewing 120 epididymides obtained with neighbouring pathological processes. Amyloid depo...

This study aimed to elucidate seasonal reproductive patterns by associating the immunolocalization of steroidogenic enzymes responsible for estrogen and androgen synthesis, cytochromes P450 aromatases (P450 arom), 17-hydroxylase/17,20-lyase (P450c17) respectively, as well redox partner NADPH cytochrome oxido-reductase (CPR) in male mud turtle (Kinosternon scorpioides). The animals were collecte...

background: there are many studies focused on long or short storage time of epididymal sperm (eps) of different species. there are limited studies on preservation or cryopreservation of the domestic goat eps. objective: the aim of the present study was to evaluate the effects of ex vivo cold-storage on freezing of eps from goat (capra hircus). materials and methods: in a split-plot design the c...