Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...

Background: Epigenetic aberration such as DNA methylation and histone modifications appear to be involved in various diseases such as Endometriosis. Here, we investigated the epigenetic regulation of HOXA10 promoter, as a crucial gene, responsible for uterine organogenesis, functional endometrial differentiation and endometrial receptivity, and its correlation with mRNA expression of this gene ...

Background: Over the past several years, the rapidly increasing use of mobile phones has raised global concerns about the biological effects of exposure to radiofrequency (RF) radiation. Numerous studies have shown that exposure to electromagnetic fields (EMFs) can be associated with effects on the nervous, endocrine, immune, cardiovascular, hematopoietic and ocular systems. In spite of genetic...

Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...

microglia is the effector cell of the innate immune system in central nervous system (cns). these cells mediate inflammatory responses in injuries. besides external factors, microglial function is also controlled by internal factors, including epigenetic regulations. mechanisms of epigenetic regulation mainly consist of dna methylation, histone modifications and use of non-coding rnas. recent s...

in recent years of experience fetal hemoglobin (hbf) induction considers as novel therapeutic approach for β-thalassemia and sickle cell in therapeutic approaches. several pharmacologic agents such as hydroxyurea, azacytidine, butyrate deriviates and immunomodulator drugs like pomalidomide and lnalidomide could able to up-regulate hbf level with different molecular and epigenetic paterns (1-4)....

Background Cytochrome aromatase p450, encoded by the gene CYP19A1, is a key enzyme for estrogen biosynthesis. Among the multiple promoters of CYP19A1, the proximal promoter PII is the most active ones in ovary and endometrium. Endometriosis is a chronic estrogen dependent gynecological condition characterized by the presence of ectopic glands and stroma outside the uterine cavity. Recently, evi...