Background: Epileptic spasms (ES) are a devastating seizure type with poor neurodevelopmental outcome; 1/3 resistant to treatment first line therapies. Recently attention has been drawn the ketogenic diet (KD) as potentially effective therapy, though data regarding optimal time of initiation, and its sustained effectiveness, lacking. Methods: Retrospective chart review all patients ES treated K...

INTRODUCTION PRINCIPLES FOR TERMS AND DEFINITIONS DATA SOURCES I GENERAL TERMS 1.0 SEMIOLOGY 2.0 EPILEPTIC SEIZURE 3.0 ICTUS 4.0 EPILEPSY 5.0 FOCAL 6.0 GENERALIZED 7.0 CONVULSION II TERMS DESCRIBING EPILEPTIC SEIZURE SEMIOLOGY 1.0 MOTOR 1.1 ELEMENTARY MOTOR 1.1.1 TONIC 1.1.1.1 EPILEPTIC SPASM 1.1.1.2 POSTURAL 1.1.1.2.1 VERSIVE 1.1.1.2.2 DYSTONIC 1.1.2 MYOCLONIC 1.1.2.1 NEGATIVE MYOCLONIC 1.1.2....

Hyperekplexia (startle disease) is a rare non-epileptic disorder characterised by an exaggerated persistent startle reaction to unexpected auditory, somatosensory and visual stimuli, generalised muscular rigidity, and nocturnal myoclonus. The genetic basis is a mutation usually of the arginine residue 271 leading to neuronal hyperexcitability by impairing glycinergic inhibition. Hyperekplexia i...

PurposeEating epilepsy was previously known as a kind of focal reflex epilepsy. However, the development eating-induced multiple generalized seizures and associated EEG changes were rarely reported. Herein, we present 13-year-old patient with since age 5.Case presentationThe male had suffered from late-onset epileptic spasms during meal 5. Meanwhile, he also experienced spontaneous period sleep...

background & importance: primary hemifacial spasm is usually caused by microvascular compression of the facial nerve at its root exit zone at brainstem without any space-occupying pathology. secondary or so-called symptomatic hemifacial spasm has an additional underlying pathology e.g. tumors leading to the microvascular compression. we review and discuss the pathophysiology and the literature ...

Traditionally, subcortical structures such as the cerebellum are supposed to exert a modulatory effect on epileptic seizures, rather than being the primary seizure generator. We report a 14-month old girl presenting, since birth, with seizures symptomatic of a right cerebellar dysplasia, manifested as paroxystic contralateral hemifacial spasm and ipsilateral facial weakness. Multimodal imaging ...

A convulsion or major fit is a sudden outburst of motor spasm, or involuntary movement, of the whole or of part of the body, usually associated with loss of consciousness. In a minor fit there is a loss or dimming of consciousness without muscular twitching. The mechanism immediately responsible for the fit is generally accepted to be an excessive discharge of cortical neurones, in a state of p...

dobutamine stress echocardiography (dse) has been widely used as a diagnostic and prognostic modality in the management of stress. dse is associated with limited complications and adverse effects on the health of patients. in this case report, we described a 42-year-old female patient with dobutamine-induced coronary artery spasm with history of exertional dyspnea, which had deteriorated recent...

BACKGROUND We reported less provoked spasm in the left circumflex artery (LCX) by acetylcholine testing compared with the left anterior descending artery (LAD) and right coronary artery (RCA), so we investigated the clinical characteristics of provoked spasm in the LCX by ergonovine (ER) testing.Methods and Results:We retrospectively analyzed 1,185 consecutive cases of intracoronary ER testing ...

This article reviews the ictal and interictal EEG findings associated with a select group of generalized seizures. These include absence seizures, myoclonic seizures seen in juvenile myoclonic epilepsy, idiopathic generalized tonic clonic seizures, infantile spasms, and atypical absence, tonic, and atonic seizures associated with the Lennox Gastaut syndrome.