نتایج جستجو برای: epitope maping

تعداد نتایج: 19160  

Journal: :iranian journal of veterinary research 2013
m. cai f. zhu h. wu p. shen

infectious bursal disease (ibd), a highly contagious and devastating disease in young chicken, is causedby infectious bursal disease virus (ibdv). to improve the immunogenicity of recombinant ibdv subunitvaccine, an attempt was made to find a new way to prepare ibd vaccine containing glycosylated mvp2antigen. firstly, ibdv mvp2 gene (with a nucleic acid sequence encoding b cell epitope of ibdv(...

2015
Enrico Malito Andrea Carfi Matthew J. Bottomley Charles A. Collyer

The use of protein X-ray crystallography for structure-based design of small-molecule drugs is well-documented and includes several notable success stories. However, it is less well-known that structural biology has emerged as a major tool for the design of novel vaccine antigens. Here, we review the important contributions that protein crystallography has made so far to vaccine research and de...

Journal: :modares journal of medical sciences: pathobiology 2012
fatemeh motevalli arash memarnejadian seyed mehdi sadat golnaz bahramali farzin roohvand

objective: animal studies show that vaccination with epitope-based peptides results in protective immunity. however, immunodominance should be regarded as a major challenge in this area. considering the advantages of epitopic-vaccines against hepatitis c virus (hcv) infection, herein, we compared the occurrence of immunodominance following mice immunization with three different hcv epitopic-pep...

Journal: :Frontiers in bioscience 2012
Lawrence Jin Kiat Wee Shen Jean Lim Lisa F P Ng Joo Chuan Tong

In the past decade, information technology has enabled synergistic advances in key domains of immunological research including the development of diagnostics and vaccines. Computational methods of epitope mapping now play instrumental roles in bench experiments, by facilitating the selection of immunogenic targets and the modeling of downstream cellular responses. In this article, we summarize ...

Journal: :Frontiers in Molecular Biosciences 2023

The function of an antibody is intrinsically linked to the epitope it engages. Clonal clustering methods, based on sequence identity, are commonly used group antibodies that will bind same epitope. However, such methods neglect fact with highly diverse sequences can exhibit similar binding site geometries and engage common epitopes. In a previous study, we described SPACE1, method structurally ...

Journal: :BIO web of conferences 2021

Infectious diseases have become part of human civilization as a constant phenomenon throughout time. The Human Immunodeficiency Virus (HIV) is virus that can cause immune system weakness by attacking cells CD4 receptors and CCR5 or CXCR4 chemokine coreceptors, namely helper T macrophages dendritic cells. Therefore, people infected with this will be vulnerable to opportunistic infections cancer....

Journal: :genetics in the 3rd millennium 0
mohammad taghi beygi nassiri reza pasandideh masoud reza seyfi abad shapouri

bovine ephemeral fever (bef) is an acute epidemic disease in cattle and water buffalo, spanning tropical and subtropical zones of asia, australia, and africa. in recent years, bef has been distributed in many provinces of iran and caused economic losses. in this study the sequence encoding the g1 epitope of bovine ephemeral fever virus (befv) g glycoprotein was amplified by pcr, ligated into th...

Journal: :iranian journal of basic medical sciences 0
roghayeh rahimi department of immunology, faculty of medical sciences, tarbiat modares university, tehran , iran massoumeh ebtekar department of immunology, faculty of medical sciences, tarbiat modares university, tehran , iran seyed mohammad moazzeni department of immunology, faculty of medical sciences, tarbiat modares university, tehran , iran ali mostafaie biotechnology research center, kermanshah university, kermanshah, iran mehdi mahdavi department of virology, pasteur institute of iran, tehran, iran

objective(s):multi-epitopic protein vaccines and direction of vaccine delivery to dendritic cells (dcs) are promising approaches for enhancing immune responses against mutable pathogens. escherichia coli is current host for expression of recombinant proteins, and it is important to optimize expression condition. the aim of this study was the optimization of multi-epitopic hiv-1 tat/pol/gag/env ...

2011
Azmat Ullah Richard Lai

Information Systems are increasingly becoming essential to the success of business organizations. They play a central role in the success of almost all components of the organization such as business decision-making, business strategy formulation, business goal modeling, managing organizational resources, structure, managing organizational data etc. However, protecting information systems and o...

Journal: :The Analyst 2011
Dar-Fu Tai Yi-Fang Ho Cheng-Hsin Wu Tzu-Chieh Lin Kuo-Hao Lu Kun-Shian Lin

A quantitative method using artificial antibody to detect creatine kinases was developed. Linear epitope sequences were selected based on an artificial-epitope mapping strategy. Nine different MIPs corresponding to the selected peptides were then fabricated on QCM chips. The subtle conformational changes were also recognized by these chips.

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