t is well known that most ubiquitous microorganisms, harmless in the vast majority of the general population, are pathogenic in children with inherited and acquired immunodeficiency. These children generally suffer from severe infectious diseases caused a variety of microbes, including viruses (e.g. herpes simplex virus), bacteria (e.g. Streptococcus pneumoniae and Mycobacteria) and fungi (e.g....

Post-transplant lymphoproliferative disorders (PTLD) are lymphoid or plasmacytic proliferations that develop in immunosuppressed individuals, particularly in recipients of solid organs, bone marrow, or stem cell allograft. Although rare in the general population, the prevalence of PTLD is increasing among transplant patients, particularly as transplantations have become more frequent procedures...

Over the last 20 years, nucleic acid amplification tests (NAATs) have become a major tool for detection of microorganisms, for diagnostic testing, and for research purposes in the field of infectious diseases. NAATs offer significant sensitivity and speed compared to culture and do not require viable organisms. However, validated, commercially available, U.S. Food and Drug Administration-cleare...

In a previous report of two patients with familial glucocorticoid resist ance due to reduced numbers of glucocorticoid receptors (GR), we have shown decreased numbers of GR in peripheral mononuclear cells and cultured fibroblasts but normal affinity of GR in both patients. In this study, peripheral lymphocytes from these patients, one patient's son and daughter, and normal subjects were transfo...

Epstein-Barr Virus (EBV) is a human herpesvirus, infecting 95% of humans, that is causally associated with the benign B-cell proliferative disorder, infectious mononucleosis. EBV has also been etiologically associated with several cancers, such as Burkitt's lymphoma, AIDSrelated immunoblastic lymphomas, post-transplant lymphomas, nasopharyngeal carcinoma, and gastric carcinoma. Very few viral g...

A monoclonal antibody, selected for reactivity with the EpsteinBarr virus (EBV)-encoded antigen EBNA-1, exhibited strong reactivity with the synovial lining cells in joint biopsies from 10 of 12 patients with rheumatoid arthritis (RA) and adherent cells eluted from these tissues. No staining of RA synovial membrane frozen tissue sections or eluted synovial-lining cells was obtained with monoclo...

Introducción: El lupus eritematoso sistémico (LES), prototipo deenfermedad autoinmune, cursa con empujes y remisiones. Dada ladiversidad de presentaciones posibles, su diagnóstico tratamientoson un reto para el clínico, se requiere tener alto índice desospecha.Objetivo: presentar caso clínico adolescente que debutacon LES a forma anemia hemolítica, probablemente gatillado porinfección por virus...

The genomes of herpesviruses are linear double-stranded DNA molecules ranging in size from 120 kb to more than 200 kb. Although the many different herpesviruses display a wide variety of tissue tropisms and vary enormously in the way in which they interact with their natural hosts, one common feature of the biology of all herpesviruses is the mechanism by which they replicate their genomes duri...

Background: Multiple sclerosis (MS) is a chronic, demyelinating disease of the CNS in which autoimmunity to myelin plays a role in pathogenesis. Infection with common viruses, particularly EpsteinBarr virus (EBV), is postulated to contribute to the pathobiology of MS. Epidemiological studies suggest an association between infection with EBV and risk of MS. To characterize the IgG antibody to th...