MicroRNAs (miRNAs) are a class of endogenous, small non-coding RNAs which play important roles in various biological and cellular processes, including chemoresistance. The expression level of miR-299-3p was dysregulated in doxorubicin-resistance lung cancer cell lines. However, the exact role of miR-299-3p in doxorubicin-resistance is still unknown. In the present study, miR-299-3p was down-exp...

BACKGROUND MicroRNAs (miRNAs) are effective regulators of gene expression that play a pivotal role in the pathogenesis of colorectal cancer (CRC) and various other cancers. The high prevalence of aberrant miRNA expression in CRC suggests that they can be used as biomarkers and anticancer molecules for therapeutic purposes. There is evidence that microRNA-299-5p (miR-299-5p) is associated with v...

We report on simultaneous observations of the local starburst system Arp 299 with NuSTAR and Chandra, which provides the first resolved images of this galaxy up to energies of ∼ 45 keV. Fitting the 3–40 keV spectrum reveals a column density of NH ∼ 4×10 24 cm, characteristic of a Compton-thick AGN, and a 10−30 keV luminosity of 1.2×10 ergs s. The hard X-rays detected by NuSTAR above 10 keV are ...

INTRODUCTION ..................................................................... 296 DIRECT EFFECTOR FUNCTIONS OF S-IgA ..................................................................... 297 Inhibition of Microbial Adherence and Colonization ..................................................................297 Toxin and Enzyme Neutralization ...................................................

Alcohol can affect the hypothalamo-pituitary-gonadal axis leading to impotence and sterility by various mechanisms of actions. In this study evaluation of the effect of three herbomineral formulations, alone and as combinations was done in alcohol exposed and normal rats. The preparations used showed beneficial effects of various degrees with respect to the sexual behavior of animals. There was...

Abstract LV thrombus is a complication of AMI. It estimated that 40-60% patients with large anterior wall MI will develop thrombus. The risk highest during the first 3 months following Accurate and timely detection important as it poses high for thromboembolic events. Advances in technology have improved rate intracardiac thrombi, but several uncertainties still remain regarding optimal treatme...

http://www.sciencemag.org/cgi/content/full/299/5607/682 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/299/5607/682/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...

http://www.sciencemag.org/cgi/content/full/299/5606/565 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/299/5606/565/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...