Introduction Aberrant activation of Extracellular Signal-Regulated Kinase (ERK) signaling is associated with Alzheimer’s disease (AD) pathogenesis. For example, enhanced ERK signal mediated by Apolipoprotein E4 (APOE4), which a critical genetic risk factor for AD, increases the transcription amyloid precursor protein (APP). We hypothesize that O-linked N-acetylglucosamine (O-GlcNAc) regulates p...

Long-lasting long-term potentiation (L-LTP) is a cellular mechanism of learning and memory storage. Studies have demonstrated requirement for extracellular signal-regulated kinase (ERK) activation in L-LTP produced by diversity temporal stimulation patterns. Multiple signaling pathways converge to activate ERK, with different being required To answer whether how patterns select ERK activation, ...

The overactive hypothalamic–pituitary–adrenal (HPA) axis is believed to trigger the overproduction of corticosterone, leading neurotoxicity in brain. Fisetin a flavonoid commonly found fruits and vegetables. It has been suggested possess various biological activities, including antioxidant, anti-inflammatory, neuroprotective effects. This study aims explore potential properties fisetin against ...

Generalized tonic-clonic seizures (GTCS) are the main risk factor for sudden unexpected death in epilepsy (SUDEP). Also, among several mechanisms underlying SUDEP there is cardiac dysfunction. So, we aimed to evaluate impact of number on heart function and morphology rats with epilepsy. Rats were randomized into three groups: Sham (without epilepsy), 5 S, 10 S groups, referred as a total or GTC...

urokinase plasminogen activator receptor (upar) and its ligands play a major role in many tumors by mediating extracellular matrix degradation and signaling cascades leading to tumor growth, invasion and metastasis. recently we introduced upar decapeptide antagonist with cytotoxic effect on mda-mb-231 cell line. in this study we assessed the alteration in upar downstream signaling following tre...

The extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAPK) pathway involves a three-step cascade of kinases that transduce signals and promote processes such as cell growth, development, apoptosis. An aberrant response this is related to the proliferation diseases tumors. By using simulation modeling, we document arginine methyltransferase 5 (PRMT5) modulates MAPK thus avo...


 Purpose: To study the effect of dexmedetomidine (Dex) on AKTERK signaling pathway and EMT- related proteins in high glucose-induced apoptosis human kidney tubular epithelial cells.
 Methods: HK-2 cells were assigned to control, high-glucose Dex groups. Levels ROS determined using live cell station. Flow cytometry was used measure cycle while Western blot applied assay levels PI3K, A...