نتایج جستجو برای: escc

تعداد نتایج: 1732  

2015
Jingjing Cheng Weiran Liu Xianliang Zeng Bin Zhang Yihang Guo Minghan Qiu Chao Jiang Huanhuan Wang Zhiqiang Wu Maobin Meng Hongqing Zhuang Lujun Zhao Jihui Hao Qingqing Cai Dan Xie Qingsong Pang Ping Wang Zhiyong Yuan Dong Qian

Radiotherapy is widely applied for treatment of esophageal squamous cell carcinoma (ESCC). The Rad51-related protein XRCC3 plays roles in the recombinational repair of DNA double-strand breaks to maintain chromosome stability and repair DNA damage. The present study aimed to investigate the effect of XRCC3 on the radiotherapy response of ESCC and the underlying mechanisms of the roles of XRCC3 ...

Journal: :International journal of oncology 2013
Junhye Kwon Tae-Sup Lee Hae Won Lee Moon Chul Kang Hyeon-Joon Yoon Ji-Hee Kim Jong Ho Park

Esophageal squamous cell carcinoma (ESCC), the most common subtype of esophageal cancer in East Asian countries, is a devastating disease characterized by distinctly high incidence and mortality rates. Our previous expression profile analysis showed that integrin alpha 6 (ITGA6) is highly expressed in ESCC tissues. To validate cell surface expression of ITGA6 as a novel target in ESCC, we inves...

Journal: :Archives of Iranian medicine 2013
Gholamreza Roshandel Alireza Nourouzi Akram Pourshams Shahryar Semnani Shahin Merat Masoud Khoshnia

Esophageal cancer (EC) is the eighth common cancer and the sixth most common cause of death from cancer worldwide. Esophageal squamous cell carcinoma (ESCC) remains the most common type of EC in the developing world and an important health problem in high-risk areas. Most of ESCC cases present in late stages, resulting in delayed diagnosis and poor prognosis. Prevention is the most effective st...

Journal: :Oncology Letters 2021

Cancer‑associated fibroblasts (CAFs) in the tumor microenvironment play an essential role progression of esophageal squamous cell carcinoma (ESCC). The present study aimed to investigate expression CAF‑related molecules, versican, periostin and lumican, cancer stroma, provide prognostic stratification for patients with ESCC after surgery. A total 106 who underwent curative esophagectomy without...

2017
Gang Wang Jianjun Tang Weixiang Zhan Ruhua Zhang Meifang Zhang Dan Liao Xin Wang Yuanzhong Wu Tiebang Kang

The poor clinical outcome and prognosis of esophageal squamous cell carcinoma (ESCC) is mainly attributed to its highly invasive and metastatic nature, making it urgent to further elicit the molecular mechanisms of the metastasis of ESCC. The function of each polycomb chromobox (CBX) protein in cancer is cell-type-dependent. Although CBX8 has been reported to promote the esophageal squamous cel...

2017
Yuhong Fan Haifeng Zhou Xueliang Wu Xiaoning Shi Likun Wang Linxi Zhang Yonghong Shi

In recent years, many studies have reported on role of Caveolin-1 in tumor, but little attention has been paid on its function in esophageal squamous cell carcinoma (ESCC). In this study, we attempt to provide molecular biomarkers for early diagnosis of ESCC through examining the expression of caveolin-1 and the relationship between Caveolin-1 and MMP-2, β-catenin in ESCC. ESCC tissues (110 cas...

2003
Lei Zhang Wenfu Lu Xiaoping Miao Deyin Xing Wen Tan Dongxin Lin

The development of esophageal squamous cell carcinoma (ESCC) has been linked to exposure to carcinogens such as nitrosamines that cause various alkyl DNA damages and O-methylguanine±DNA methyltransferase (MGMT) is a primary defence against alkylation-induced mutagenesis and carcinogenesis. This study was to investigate the role of inactivation of MGMT by promoter hypermethylation and its relati...

2017
Yuji Kumakura Susumu Rokudai Misaki Iijima Bolag Altan Tomonori Yoshida Halin Bao Takehiko Yokobori Makoto Sakai Makoto Sohda Tatsuya Miyazaki Masahiko Nishiyama Hiroyuki Kuwano

This study aims to explore the expression level of ΔNp63 in esophageal squamous cell carcinoma (ESCC). To investigate the association between ΔNp63 (p40) expression and ESCC biology, we compared the levels of ΔNp63 expression in normal and tumor tissues, with a specific focus on the diagnostic value of ΔNp63 in ESCC. We analyzed 160 consecutive patients with ESCC who underwent surgical resectio...

2014
Naohiro Uraoka Naohide Oue Naoya Sakamoto Kazuhiro Sentani Htoo Zarni Oo Yutaka Naito Tsuyoshi Noguchi Wataru Yasui

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignancies worldwide. In the present study, to identify novel prognostic markers or therapeutic targets for ESCC, we reviewed a list of genes with upregulated expression in ESCC compared with normal esophagus, as identified by our serial analysis of gene expression (SAGE) analysis. We focused on the NRD1 gene, which encodes t...

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