Introduction: Estrogen is one of the gonadal hormones that has multiple beneficial actions in central nervous system and involves in learning and memory. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that impairs patient memory. The human nucleus basalis of Meynert (nBM) is severely affected in Alzheimer's disease. So in this study the effect of peripheral (intramuscul...

Introduction: Postoperative neurological deficit is the most devastating complication after thoracoabdominal aortic aneurysm repair. Despite demonstrated neuroprotective effects of estradiol, its protective efficacy against spinal cord ischemia-reperfusion and underlying mechanisms are not yet elucidated. Methods: Two groups, each of 10 New Zealand white male rabbits, were studied. Control g...

Although the ovaries produce majority of estrogens in women before menopause, estrogen is also synthesized peripheral tissues such as adipose tissue (AT). The typical female AT distribution, concentrated subcutaneous and femoro-gluteal regions, estrogen-mediated, but significance synthesis premenopausal poorly understood. Serum visceral homogenates from 28 undergoing non-malignant surgery were ...

this study was investigated the effects of dietary estradiol-17? (e2) on growth, body composition and blood indices in acipenser stellatus. fish (40.9 ? 1.1 g average initial weight; n = 60 per group) were fed with three different diets containing 0 (control), 25 and 50 mg kg-1 dietary estradiol contents to apparent satiation for seven months. the results suggested that growth rate were decreas...

preeclampsia is a major cause of morbidity and mortality during pregnancy. several independent investigators have demonstrated the association of androgens with hypertension. the main purpose of this study was to determine whether maternal levels of sex hormones, especially testosterone, are higher in patients with preeclampsia than in matched normotensive control subjects. serum levels of test...

Introduction: The 17β-estradiol acts as a neurosteroid in the brain and modulates nociception by binding to the estrogen receptors and also by allosteric interaction with other membrane-bound receptors like glutamate receptors. Paragigantocellularis lateralis nucleus (LPGi) is one of the important brain regions implicated in the pain modulation. So, this study was designed to evaluate the ...

Background: The presence of estrogen receptor beta and aromatase in the germ cell has highlighted the physiological role of the traditionally female hormone, estrogen, in spermatogenesis. Estrogen receptor alpha knockouts and aromatase knockouts have further accentuated the role of estrogen in germ cell maturation. To delineate effects of high intratesticular estradiol in the seminiferous epith...