Recent studies suggest that, in female monkeys and rats, estrogens elicit dendritic spine synapse formation in the prefrontal cortex, an area that, similar to the hippocampus, plays a critical role in cognition. However, whether gonadal hormones induce synaptic remodeling in the male prefrontal cortex remains unknown. Here we report that gonadectomy reduced, whereas administration of 5alpha-dih...

BACKGROUND In pregnant rats, structural luteal regression takes place after parturition and is associated with cell death by apoptosis. We have recently shown that the hormonal environment is responsible for the fate of the corpora lutea (CL). Changing the levels of circulating hormones in post-partum rats, either by injecting androgen, progesterone, or by allowing dams to suckle, was coupled w...

Neonatally castrated (MNC) and control male rats (MC) and female rats treated neonatally with estradiol benzoate (FNE) and female controls (FC) were studied. In Exp. 1 spatial memory was assessed using a 12-arm radial maze. During acquisition, MC and FNE groups were more accurate in choice behavior than FC and MNC groups. In Exp. 2 the discriminative control exerted by different types of cues w...

ACTH infusion at the time of unilateral adrenalectomy inhibits the early rapid compensatory growth (CAG) in the remaining adrenal. We examined the hypothesis that different duration of surgery and/or the enhanced response to the stress of surgery, induced by estradiol treatment, might modify CAG. Adult male rats untreated, estradiol benzoate treated (EB) 300 microg/kg or vehicle treated (VE) fo...

The anti-estrogen, Cl 628, was used to suppress the lordosis response induced by sequential injections of estrogen and progesterone in ovariectomired (OVX) female rats. Appropriate doses of Cl 628 completely abolished sexual receptivity in females administered estradiol benzoate (EB) in sesame oil. This behavioral effect could be attenuated by providing increased quantities of EB or decreased q...

STERN, J. J. AND M. MURPHY. The effects of thyroxine and estradiol benzoate on wheel running activity in female rats. PHY~OL. BY.HAY. 9 (1) 79-82, 1972.--The administration of 30-50 ~g thyroxine to female rats for 21 days disrupted wheel running activity and cyclic vaginal cornification. Thyroxine produced a decrease in spontaneous activity and the number of activity peaks, and resulted in prol...

The objectives in this study were to determine whether treatment with progesterone (P4) via an intravaginal device would induce estrus and development of corpora lutea (CL) with typical life spans and whether treatment with estradiol benzoate (EB) following device removal would enhance the responses. At treatment initiation (d 0), suckled beef cows (n = 362) that were anestrous received one of ...

At each of three locations, 400 steers and an equal number of heifers were randomized to 10 treatment groups. The purpose of the studies was to evaluate the response of feedlot steers and heifers to single implants containing a combination of estradiol benzoate (EB) and trenbolone acetate (TBA) at two different ratios each at three doses. The selected ratios corresponded to 1E2(estradiol-17 bet...

GORSKI, ROGER. Modijcation of ovulatory mechanisms by postnatal administration of estrogen to the rat. Am. J. Physiol. 205(5) 1 842-844. I g63.pThe current studies have demonstrated that the single injection of IOO pug estradiol benzoate to 5-day-old female rats results in permanent sterility. When adult, these rats exhibit anovulatory vaginal cycles in which the stage of vaginal cornification ...

Introduction: Estrogen is one of the gonadal hormones that has multiple beneficial actions in central nervous system and involves in learning and memory. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that impairs patient memory. The human nucleus basalis of Meynert (nBM) is severely affected in Alzheimer's disease. So in this study the effect of peripheral (intramuscul...