In order to accurately determine sex hormone dependency and hormone responsiveness in human esophageal carcinoma, the effects of sex hormones on the growth of esophageal carcinoma cell lines, KSE-1 and KSE-2 cells, were examined in vitro and in vivo. Cell proliferation of cultured KSE-1 cells was inhibited by treatment of estradiol and enhanced by dihydrotestosterone (DHT), whereas KSE-2 cells ...

OBJECTIVE The aim of this study was to quantify the magnitude of risk reduction for venous thromboembolism events associated with an estradiol transdermal system relative to oral estrogen-only hormone therapy agents. METHODS A claims analysis was conducted using the Thomson Reuters MarketScan database from January 2002 to October 2009. Participants 35 years or older who were newly using an es...

Early exposure to the steroid sex hormone testosterone and its estrogen metabolite estradiol masculinize neural tissue during a developmental critical period. Many aspects of neuron anatomy and physiology are permanently altered, including later sensitivity to estradiol. Although it is well established that early hormone exposure alters neuronal responsiveness regarding classical estradiol acti...

RATIONALE: There is a complex interplay between epilepsy, antiepileptic drugs, and reproductive endocrine disorders. Epilepsy itself may influence on the hormonal balance, hormones may affect epilepsy, hormones may influence on the efficacy and metabolism of antiepileptic drugs and antiepileptic drugs may alter the hormone levels.To better understand the interaction of antiepileptic drugs and p...

Background Neuronal models of both familial and sporadic cases Alzheimer’s Disease (fAD/sAD) were generated from the human-derived induced pluripotent stem cells (iPSCs) AD patients. Using this in vitro cellular models, AD-like phenotypes was analyzed with or without 17β-estradiol, sex hormone that are supposed to be involved pathogenesis. Method 5 lines iPSCs comprised 1 healthy control, 2 fAD...

Abstract Objective To evaluate the genetic effects of sex hormone traits on development mental in middle-aged adults. Methods The SNPs associated with were derived from a two-stage genome-wide association study (GWAS). Four selected current study, including hormone-binding globulin (SHBG), testosterone, bioavailable testosterone and estradiol. polygenic risk score (PRS) calculated individual-le...

background: estrogens include estoril (e3), estradiol and estrone (e1). these chemicals are produced in human and animal bodies as well as in synthetic chemicals (drugs). estrogens can enter water sources in different ways. when these chemicals enter the human body through water and wastewater, they have the ability to mimic or disrupt the normal estrogen activities in humans and animals. estro...

Aim: The aim of this study was to determine the effect paternal age on miscarriage rates in couples undergoing vitro fertilization/intracytoplasmic sperm injection treatment cycles. Material and Methods: Patients were classified into two groups. group consisted patients whose pregnancy resulted a (n=73) control which had live singleton birth (n=256). Demographic characteristics, indications, du...

The authors conducted a nationwide cohort study to evaluate the association between postmenopausal hormone therapy and meningioma incidence in Finland. All women who had used hormone therapy at least for 6 months at the age of 50 years or older during 1994-2009 were included. Women who had used postmenopausal hormone therapy were identified from the medical reimbursement register of the Social ...

Background: The definition of World Health Organization (WHO) to the infertile couple is failure female get pregnancy in spite having regular sexual activity for at least 1 year without using any contraceptive methods, worldwide it estimated that 15 % reproductive-age couples are struggling with infertility.
 In many cases, infertility cannot be treated, new treatment options promising val...