Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...

Clinical observations suggest that postmenopausal women have a higher incidence of aneurysmal rupture than premenopausal women. We hypothesize that a relative deficiency in estrogen may increase the risks of aneurysmal growth and subarachnoid hemorrhage in postmenopausal women. We assessed the effects of estrogen and selective estrogen receptor subtype agonists on the development of aneurysmal ...

schizophrenia is a debilitating and pervasive mental illness with devastating effects on many aspects of psychological, cognitive and social wellbeing. epidemiological and life-cycle data point to significant differences in the incidence and course of schizophrenia between men and women, suggesting that estrogen plays a “protective” role . adjunctive estrogen therapy has been shown to be effect...

Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 w...

background: breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. the purpose of this study was to determine the relationship between estrogen and progesterone receptors with her-2, ki67, p53, and clinicopathologica...

A fibroadenoma was diagnosed in the mammary gland of a lamb by immunohistochemical method andmeasurement of oestradiol hormone. The tumor was characterized by an encapsulated firm mass with acreamy-white cut surface. Histologically, it consisted of variably-sized sinus ducts, covered by a single ormultiple layers of proliferated epithelial cells, and embedded in a loose connective tissue. Immun...

background : this study evaluates estrogen and progesterone expressions in patients with ovarian tumors (both benign and malignant) and their correlation with various clinicopathological prognostic parameters. receptors for estrogen and progesterone are predictive and prognostic markers of endometrial and breast cancers. however, their clinical significance in epithelial ovarian cancer is not c...

Estrogen-responsive endometrial cancer (EC) is prevalent in uterine cancer. Its precise molecular mechanisms remain to be elucidated partly because of limited availability estrogen-sensitive EC models recapitulating clinical pathophysiology. We previously established patient-derived cell (EC-PDC) spheroid culture with high expression estrogen receptor α (ERα). Using this EC-PDC, we study the tr...