OBJECTIVES Experimental studies on sepsis have demonstrated that ethyl pyruvate is endowed with antioxidant and anti-inflammatory properties. This study aimed to investigate the effects of ethyl pyruvate on leukocyte-endothelial interactions in the mesenteric microcirculation in a live Escherichia coli-induced sepsis model in rats. METHODS Male Wistar rats were administered an intravenous sus...

The title compound is a hydantoin derivative that has been synthesized through three-component reaction of ethyl pyruvate, p-anisidine and phenyl isocyanate. This paper provides comprehensive spectral dataset for the compound, including 1H 13C{1H} NMR, IR, HRMS, X-ray crystallography analyses. A tentative mechanism comprising two complementary pathways provided based on additional experiments w...

EP is a potent inhibitor of HMGB1 release that has significant anti-inflammatory activities and exerts a protective effect in animal models of inflammation. As inflammation is linked to cancer growth, we hypothesized that EP would have anti-tumor activity and explored its effects in a liver tumor model. Mice injected intraportally with MC38 colorectal cancer cells led to the growth of visible h...

OBJECTIVE To investigate the effects of administered ethyl pyruvate (EP), a novel anti-inflammatory agent, on oxidoinflammatory and apoptotic pathways in the lung tissue of rats in a full-thickness burn model. METHODS The study took place in Ankara Research and Training Hospital Animal Laboratory, Turkey in June 2006. Thirty-two rats were randomly divided into 4 groups in equal numbers as sha...