Following reports by Franke and Fuchs (1955) and by Bertram, Bendfeldt, and Otto (1955) that oral administration of the sulphonamide Nisulphanilyl-N2-n-butylcarbamide could successfully control diabetes, considerable interest has centred on this compound. It has been used on a large scale in Germany, with apparently successful results, in a proportion of cases, chiefly elderly non-ketonic diabe...

A validated and sensitive spectrophotometric method is developed for the quantitation of nicorandil in pharmaceutical formulations. The method is based on the reduction of nitroxy ethyl group of nicorandil to carbonyl derivative and nitrite ion by Zn/NH4Cl. The nitrite ion undergoes diazotization with sulphanilamide in presence of HCl followed by coupling with N-(1-naphthyl) ethylenediamine dih...

Objective: The objective of the study was to develop a simple and rapid chromatographic method for quantification escitalopram oxalate flupentixol dihydrochloride in combined dosage form plasma.
 Methods: separation achieved with sun fire C8 [150×4.6 mm] 3.5 µm column an isocratic mobile phase containing mixture potassium dihydrogen orthophosphate buffer: methanol: acetonitrile [30:60:10 v...

Two spectrophotometric methods for the determination of ceftazidime (CFZM) in either pure form or in its pharmaceutical formulations are described. The first method is based on the reaction of 3-methylbenzothiazolin-2-one hydrazone (MBTH) with ceftazidime in the presence of ferric chloride in acidic medium. The resulting blue complex absorbs at lambdamax 628 nm. The second method describes the ...

An automatic direct spectrophotometric method for the simultaneous determination of nitrite and nitrate by flow-injection analysis has been developed. Nitrite reacts with 3-nitroaniline in the presence of hydrochloric acid (0.96-1.8 M HCl or pH 0.5-0.7) to form a diazonium cation, which is subsequently coupled with N-(1-naphthyl)-ethylenediamine dihydrochloride to form a stable purple azo dye, ...

o-Phthaldialdehdye reagent was used in assaying urea with a miniature centrifugal analyzer. Seventeen samples can be assayed kinetically in 2 min at a current cost of less than a penny per test. The reaction is initiated in the instrument upon simultaneous mixing of the o-phthaldialdehyde reagent containing 10 microliter of sample with dilute sulfuric acid/N-(1-naphthyl)ethylenediamine dihydroc...

Four simple, sensitive, accurate, and rapid visible spectrophotometric methods (A, B, C and D) have been developed for the estimation of sulfamethoxazole in pharmaceutical Preparation. They are based on the diazotization of sulfamethoxazole with sodium nitrite and hydrochloric acid followed by coupling with N-(1-naphthyl ethylenediamine dihydrochloride (Method A) to form pink coloured chromogen...

A new simple, sensitive, and selective spectrophotometric method was developed for the determination of nitrite. The method is based on the reaction of nitrite with sulfathiazole in acidic medium to form a diazonium cation, which is subsequently coupled with N-(1-naphthyl)ethylenediamine dihydrochloride to form a highly stable, violet azo dye. The reaction product has an absorption maximum at 5...