BACKGROUND AND OBJECTIVES Extracellular volume (ECV) is the fluid contained in all noncellular compartments of the body and is a quantity tightly controlled by the kidney. Thus, there is a strong link between ECV and kidney function. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS The Chronic Kidney Disease in Children (CKiD) study uses injected iohexol to obtain direct measures of GFR. Direct c...

Background Cardiac biomarkers have become increasingly important in cardiovascular disease. With the ability to detect focal and diffuse myocardial fibrosis, CMR is an important imaging biomarker. Diffuse myocardial fibrosis, reflected by increased extracellular volume (ECV), may underlie increased cardiovascular risk. ECV could provide a novel tool to evaluate the association myocardial-specif...

OBJECTIVE To measure and assess the significance of myocardial extracellular volume (ECV), determined non-invasively by equilibrium contrast cardiovascular magnetic resonance, as a clinical biomarker in health and a number of cardiac diseases of varying pathophysiology. DESIGN Prospective study. SETTING Tertiary referral cardiology centre in London, UK. PATIENTS 192 patients were mainly r...

Background Amyloidotic cardiomyopathy (AC) in Hereditary Transthyretin Amyloidosis (ATTR) determines prognosis and treatment options. Cardiac Magnetic Resonance (CMR) has shown its utility in the diagnosis and characterization of AC. Moreover, CMR T1 mapping techniques are useful to assess myocardial extracellular volume (ECV) fraction in AC. We hypothesized that ECV allows identification of AC...

BACKGROUND Optimal patient characterization in heart failure with preserved ejection fraction (HFpEF) is essential to tailor successful treatment strategies. Cardiac magnetic resonance (CMR)-derived T1 mapping can noninvasively quantify diffuse myocardial fibrosis as extracellular volume fraction (ECV). OBJECTIVES This study aimed to elucidate the diagnostic performance of T1 mapping in HFpEF...

Background Native T1 is increased in acute myocardial infarction. Extracellular volume fraction (ECV) can be calculated using T1 mapping following contrast. The timing of imaging following contrast in acute myocardial infarction is not established. 15 minutes has been proposed for conditions with and ECV < 0.4. 15 minutes may not be applicable in acute myocardial infarction due to infarct chara...

Background The extracellular volume fraction (ECV) by T1 mapping measures the size of the myocardial interstitium. T1 changes in blood and myocardium are used to measure the contrast partition coefficient (l), and substituting in the blood volume of distribution (directly measured on a peripheral blood sample as one minus the hematocrit [Hct]) provides the ECV. This methodology is however cumbe...

Background Quantitative extracellular volume (ECV) estimates based on T1 mapping have potential for characterizing cardiomyopathies with diffuse fibrosis and edema [1,2]. An unsupervised approach for generating pixel-wise ECV maps was recently introduced [3]. In this work we extend the algorithms to include saturation recoverybased T1 mapping and present an inline implementation of these method...

Background Measurements of myocardial extracellular volume (ECV) through cardiac magnetic resonance (CMR) based T1 mapping allow for non-invasive quantification of diffuse myocardial fibrosis. The evaluation of the right ventricle (RV), often mainly affected in congenital heart disease (CHD), is complicated by its typical morphologic characteristics a thin myocardium and a distinct trabeculatio...

Background Expansion of myocardial extracellular volume (ECV) as detected by native and post contrast T1 mapping has been associated with different types of cardiomyopathy. We hypothesize that fully quantitative evaluation of MR perfusion imaging can localize and quantify edematous ECV expansion after acute coronary events with sensitivity equivalent to ECV measurements based on T1 mapping or t...