OBJECTIVE To develop topical gel preparations of astemizole and terfenadine and to investigate the actions of the gels on the healing of incision and excision wounds in male albino rats. MATERIALS AND METHODS Gels containing 1% astemizole, with varying concentrations of carbopol 934 (polymer), were prepared. Similarly, 1% terfenadine gels were made. The formulations were evaluated for release...

OBJECTIVE To evaluate the wound healing potential of fractions from ethanol extract of Martynia annua (M. annua) Linn leaves. METHODS Ethanol extract of M. annua Linn leaves was fractionate into three different fractions (MAF-A, MAF-B and MAF-C) which were screened for wound healing potential using two models: excision and incision on rats. The thin layer chromatography (TLC) profile of all f...

The present manuscript was mainly focused to evaluate the multiherbal formulation PACT (containing extracts of Pongamia pinnata Linn., Artocarpus lakoocha, Cynodon dactylon Pers. and Tridax procumbens Linn.) for wound healing potential employing two common wound models i.e. excision wound and incision wound models. The wound contraction area and epithelialization period was measured in excision...

OBJECTIVES Compare circular defect with dog-ear deformities excision (CDDE) technique to 3:1 fusiform excision technique when removing facial lesions to analyze which technique provides superior wound closure. METHODS Identical 1-cm circular skin defects were created on bilateral cheek, forehead, and parietal scalp on three fresh cadavers. Similarly, using four fresh cadavers, identical 2-cm ...

The wound healing effect of alcoholic extract of Kaempferia galanga (K. galanga) and its effect in dexamethasone suppressed wound healing was studied in Wistar rats. Three wound models viz. incision, excision and dead space wounds were used in this study. The parameters studied were breaking strength in case of incision wounds, epithelialization and wound contraction in case of excision wound a...

The present study was performed to substantiate the traditional claim of the wound healing activity of stem bark of Albizzia lebbeck Linn. in rats. The effects of aqueous and ethanolic extracts of stem bark of A. lebbeck (5% and 10% w/v topically and 250 mg/kg and 500 mg/kg p.o.) on excision, incision and dead space wound model were examined. The extracts were administered orally for 10 days fo...

Aqueous extract of the roots of Radix paeoniae (Paeonaceae) was screened for wound healing by excision, incision and dead space wound models on Wistar rats. The parameters studied were breaking strength in case of incision wounds, epithelialisation and wound contraction in case of excision wound and granulation tissue dry weight, breaking strength and hydroxyproline content in case of dead spac...

The wound healing activity of cow urine was studied in Wistar albino rats. The efficacy of wound healing property was evaluated by excision wound model. The parameter studied was the rate of wound contraction. The studies on excision wound healing revealed that all the groups showed decreased wound area from day to day. On day 4th, the external application of urine showed significant increase i...

Present study is an attempt to investigate wound healing efficiency of Aloe verajuice on excision wound model.This study was undertaken to evaluate the wound healing properties of Aloe vera, for purpose different conc. of Aloe vera juicewere applied with respect toBetadine on excision wound in albino mice.The effect of Aloe vera juice application on excision wound contraction (area in mm 2 ) in...

iranian traditional medicine (itm) manuscripts contain prescriptions that have long been used for healing of wounds. the present study evaluates the healing effect of a poly herbal paste (php), retrieved from itm sources, containing aloe vera, commiphora myrrha and boswellia carteri using rat excision wound model. excision wounds were induced in six groups consisting of six rats each. group 1 r...