The ex utero intrapartum treatment (EXIT) procedure is a very rare technique performed in cases of fetal congenital malformations. The EXIT procedure increases the rate of survival at delivery by maintaining the uteroplacental circulation until the airway of the fetus is secured. To maintain the uteroplacental circulation, a higher dose of inhalational anesthetics and/or intravenous nitroglycer...

The mechanisms of cell cycle exit by myoblasts during skeletal muscle development are poorly understood. Cell cycle arrest is known to be a prerequisite for myoblast fusion and subsequent differentiation. Despite tremendous knowledge on myoblast fusion and differentiation, tissue-specific factors that spatio-temporally regulate the cell cycle exit are not well known. In this paper, we show that...

In this study, we use the quadratic calibration method (QCM), in which an EPID image is converted into a matrix of equivalent path lengths (EPLs) and, therefore, exit doses, so as to model doses in conformal and enhanced dynamic wedge (EDW) fields. The QCM involves acquiring series of EPID images at a reference field size for different thicknesses of homogeneous solid water blocks. From these, ...

Cyclin-dependent kinase (Cdk) both promotes mitotic entry (spindle assembly and anaphase) and inhibits mitotic exit (spindle disassembly and cytokinesis), leading to an elegant quantitative hypothesis that a single cyclin oscillation can function as a ratchet to order these events. This ratchet is at the core of a published ODE model for the yeast cell cycle. However, the ratchet model requires...

An a irradiation device is described that utilises a commercially available disc-shaped americium-241 source of 8 cm diameter. The a particles traverse a moving collimator and the source is rotated to reduce the influence of source inhomogeneities. Source, collimator and a shutter disc are mounted in a container which is flushed with helium to reduce energy losses of the a particles before reac...

An important step in the verification of the reliability of portal films as in vivo dosemeters is the evaluation of the agreement between exit dose profiles and optical density profiles measured on the portal film. To test the possibilities of a conventional portal film system in 60Co beams suitable for head and neck irradiation, we verified the agreement between relative exit doses (measured b...

The aim in this study is to develop a generalized strategy for 3D dose verification of IMRT and VMAT planes using EPID transit images in combination with Monte Carlo (MC) simulations. An EPID-based dosimetric verification procedure was developed to convert EPID-measured transit images into 2D exit photon fluence by de-convoluting with the MC-simulated EPID response kernels. The present scatter ...

The TEAM 0.5 electron microscope is employed to demonstrate atomic resolution phase contrast imaging and focal series reconstruction with acceleration voltages between 20 and 300 kV and a variable dose rate. A monochromator with an energy spread of ≤0.1eV is used for dose variation by a factor of 1,000 and to provide a beam-limiting aperture. The sub-Ångstrøm performance of the instrument remai...