نتایج جستجو برای: exoenzyme s
تعداد نتایج: 711274 فیلتر نتایج به سال:
The research was aimed to demonstrate the frequency of virulence factors genes (exoenzyme S and exotoxin A) express their relationship antibacterial resistance among Pseudomonas aeruginosa isolated from patients suffering otitis externa. results were revealed that only twenty one (32%) out 65 clinical ear swabs aeruginosa. According PCR amplification, 18 (85.7%) bacterial isolates expressed bot...
Background and Aims: Pseudomonas aeruginosa is the most important cause of various nosocomial infections and mastitis in dairy cattle and the development of antibiotic resistance. The aim of this study was to determine the antibiotic resistance of Pseudomonas aeruginosa and the presence of virulence genes in human and animal samples. Materials and Methods: In this study, 102 human and animal st...
Extracellular protein profiles from wild-type and regulatory or secretory isogenic mutants of the Pseudomonas aeruginosa exoenzyme S regulon were compared to identify proteins coordinately secreted with ExoS. Data from amino-terminal sequence analysis of purified extracellular proteins were combined with data from nucleotide sequence analysis of loci linked to exoenzyme S production. We report ...
Some bacterial products possess multiple immunomodulatory effects and thereby complex mechanisms of action. Exogenous administration of an important Pseudomonas aeruginosa virulence factor, exoenzyme S (ExoS) induces potent monocyte activation leading to the production of numerous proinflammatory cytokines and chemokines. However, ExoS is also injected directly into target cells, inducing cell ...
Intracellular targeting of the Pseudomonas aeruginosa toxins exoenzyme S (ExoS) and exoenzyme T (ExoT) initially results in disruption of the actin microfilament structure of eukaryotic cells. ExoS and ExoT are bifunctional cytotoxins, with N-terminal GTPase-activating protein (GAP) and C-terminal ADP-ribosyltransferase activities. We show that ExoS can modify multiple GTPases of the Ras superf...
Pseudomonas aeruginosa is the most common gram-negative pathogen causing pneumonia in immunocompromised patients. Acute lung injury induced by bacterial exoproducts is associated with a poor outcome in P. aeruginosa pneumonia. The major pathogenic toxins among the exoproducts of P. aeruginosa and the mechanism by which they cause acute lung injury have been investigated: exoenzyme S and co-regu...
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