Erythropoietin (EPO) is known to have numerous biological functions. While its primary function is during haematopoiesis, recent studies have shown that EPO plays important role in cytoprotection, immunomodulation, and antiapoptosis. These secondary functions of EPO are integral to tissue protection following hypoxic injury, ischemia-reperfusion injury, and spinal cord injury in the central ner...

Experimental autoimmune encephalomyelitis (EAE) is a useful model for aiding the development of new treatments for MS. All therapies approved for MS ameliorate EAE. Two approved medications, glatiramer acetate and Natalizumab, were developed directly from studies in EAE. Several trials are ongoing in MS after success in EAE, including altered peptide ligands of myelin, DNA vaccines and statins....

UV light suppresses experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS, in mice and may be responsible for the decreased incidence of MS in equatorial regions. To test this concept further, we applied commercially available sunblock preparations to mice before exposing them to UV radiation. Surprisingly, some of the sunblock preparations blocked EAE without UV rad...

background: il-17/il-23 axis plays an important role in the pathogenesis of several autoimmune diseases such as experimental autoimmune encephalomyelitis (eae) and multiple sclerosis (ms). the immunomodulatory properties of ginger are reported in previous studies. objective: to evaluate the effects of ginger extract on the expression of il-17 and il-23 in a model of eae. methods: eae was induce...

The TNF-related apoptosis-inducing ligand (TRAIL) has well-described anti-inflammatory effects in models of autoimmune disease, including experimental autoimmune encephalomyelitis (EAE). In this issue of Neuron, Aktas, Smorodchenko, and colleagues present evidence that TRAIL exerts anti-inflammatory effects, but also induces neuronal apoptosis, in EAE. This report poses the therapeutic challeng...

objective(s):experimental allergic encephalomyelitis (eae) is an autoimmune disease validated as animal model of multiple sclerosis (ms). administration of genistein, a phytoestrogenic component of soy, to mice at the onset of eae is known to attenuate the clinical signs of the disease. the potential effects of genistein on established eae is less studied. in the current study, we aimed to comp...

Experimental allergic encephalomyelitis (EAE) 1 has been widely studied as a possible experimental model for human demyelinative diseases, the two most common of which are multiple sclerosis and acute disseminated encephalomyelitis. EAE is also the only experimental autoimmune disease for which the exact amino acid sequence of an inciting molecule, basic protein of myelin, is known (1). Nearly ...

Macrophage migration inhibitory factor (MIF) has been implicated in the pathogenesis of inflammatory and autoimmune diseases. The role of MIF in the progression of experimental autoimmune encephalomyelitis (EAE) was explored using MIF-/- mice. Wild-type mice showed a progressive disease course, whereas MIF-/- mice exhibited acute signs but no further progression of clinical disease. MIF-/- mice...