نتایج جستجو برای: experimental autoimmune vitiligo
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Melanoma-associated vitiligo is the best-studied example of the linkage between tumor immunity and autoimmunity. Although vitiligo is an independent positive prognostic factor for melanoma patients, the autoimmune destruction of melanocytes was long thought to be merely a side effect of robust anti-tumor immunity. However, new data reveal a key role for vitiligo in supporting T cell responses t...
BACKGROUND Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases. METHODS To identify generalized vitiligo susceptibility loci, we conducted a genomewide association study. We genotyped 579,146 single-nucleotide polymorphisms (SNPs) in 1514 pa...
background: vitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches. the exact etiology and pathogenesis of vitiligo is not clear. many theories have been presented regarding this subject among them aautoimmune theory is the most important one. the association of vitiligo with other autoimmune disorders has been reported, but the relationship ...
Vitiligo is a common acquired depigmentation disorder of the skin manifested by the presence of white macules. The disease occurs at a frequency of approximately 1-4% of the world population. Currently, the most popular theory of vitiligo development is a multifactorial hypothesis according to which genetic conditions predispose vitiligo macules to occur as a result of specific environmental fa...
Alopecia areata and vitiligo are autoimmune diseases, both associated with multiple autoimmune comorbidities. Many studies show colocalization of these diseases at the same anatomical site. Here, we have a case where both disorders were reported to present in the same patient. Diphenylcyclopropenone (diphencyprone, DCP) is used in the treatment of alopecia areata and may induce vitiligo in some...
Lupus erythematosus and vitiligo are diseases of autoimmune origin. Reports in the literature suggest patients are more likely to suffer more than 1 autoimmune disease (30% of patients with generalized vitiligo have another autoimmune disease).1 However, there are few reports of cutaneous lupus erythematosus in association with vitiligo. We describe a 42-year-old woman with no family history of...
Background: Vitiligo is a common depigmentary disorder characterized by white patches of the skin, hair and mucous membranes due to selective destruction of melanocytes. Objective: The objective of this study was to analyze the clinical characteristics, coexisting diseases, presence of autoantibodies and autoimmune polyglandular syndrome (APS) in Estonian adult vitiligo patients. Methods:Adult ...
Vitiligo is an autoimmune depigmentation disorder that is estimated to affect about .5% of the worldwide population. Half of all cases begin in childhood. A variety of advances occurred in the past two decades that have enhanced the management of childhood vitiligo. This contribution reviews recent advances in vitiligo, including a better understanding of the pathogenesis and autoimmune comorbi...
Generalized vitiligo is a common disorder in which patchy loss of skin and hair pigmentation principally appears to result from autoimmune loss of melanocytes from affected regions. We previously characterized a unique founder population in an isolated Romanian community with elevated prevalence of generalized vitiligo and other autoimmune diseases, including autoimmune thyroid disease, rheumat...
The pathogenesis of vitiligo has been proposed as a destruction of melanocytes by autoimmune processes. Evans syndrome is the combination of autoimmune hemolytic anemia and immune-mediated thrombocytopenia. The antiphospholipid syndrome is characterized by arterial/venous thrombosis, recurrent pregnancy loss, or thrombocytopenia in the presence of antiphospholipid antibodies. We present a case ...
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