Morphine withdrawal usually results in unsuccessful outcomes. Despite partial benefits from alternative substances such as methadone, its use may not lead to the desired result due to the lack of mental tranquility during the withdrawal period. In this study, by means of an animal model, morphine itself was used to manage morphine dependence. Forty mice were divided into 5 groups, in which 4 gr...

The beta-adrenoceptor-blocking and class III effects of sotalol were assessed in 11 patients with inducible orthodromic reciprocating tachycardia. Serum sotalol concentration, maximum exercise heart rate, and electrophysiologic study data were obtained at control, at the beta-adrenoceptor-blocking dosage (407 +/- 149 mg/day, 1.4 +/- 0.5 micrograms/ml), and at the maximum well-tolerated dosage (...

In the model of active motion studied here, Brownian particles have the ability to take up energy from the environment to store it in an internal depot and to convert internal energy into kinetic energy. Considering also internal dissipation, we derive a simplified model of active biological motion. For the take-up of energy two different examples are discussed: (i) a spatially homogeneous supp...

A random sample survey of 500 acute care hospitals in the United States was conducted to evaluate the adoption of extended-interval aminoglycoside dosing (EIAD). The survey revealed that EIAD has been adopted in 3 of every 4 acute care hospitals, a 4-fold increase since 1993. Of the 74.7% of hospitals reporting EIAD, 64% had written guidelines. Equal or less toxicity (87.1%), equal efficacy (76...

data envelopment analysis (dea) models with interval inputs and outputs have been rarely discussed in dea literature. this paper, using the enhanced russell measurement proposes an extended model which permits the presence of interval scale variables which can take both negative and positive values. the model is compared with most well-known dea models of which include the ccr model, the bcc mo...

Data Envelopment Analysis (DEA) models with interval inputs and outputs have been rarely discussed in DEA literature. This paper, using the enhanced Russell measurement proposes an extended model which permits the presence of interval scale variables which can take both negative and positive values. The model is compared with most well-known DEA models of which include the CCR model, the BCC mo...

Methods In a prospective observational study we included patients started on vancomycin, from four different intensive care units (ICU) at Oslo University Hospital. Blood samples as well as ultrafiltrate samples from patients on continuous renal replacement therapy (CRRT), were collected in one dosage interval on three consecutive days 24 hours(hrs) from start. The observation time was 72 hrs. ...