The exuberant growth of neurites during development becomes markedly reduced as cortical neurons mature. In vitro studies of neurons from mouse cerebral cortex revealed that contact-mediated Notch signaling regulates the capacity of neurons to extend and elaborate neurites. Up-regulation of Notch activity was concomitant with an increase in the number of interneuronal contacts and cessation of ...

This paper develops a general test for determining the stability of an object, B, in frictionless contact with bodies A1; : : : ;Ak, in the presence of gravity, or any other force arising from a potential eld. For a small number of contacts, the stability of B depends on the surface normals and surface curvatures of the contacting bodies. For a su ciently large number of contacts, the surface n...

soil management (sm) is critical to human well-being that it is more important now because of meeting the high demands for food production and satisfying the needs of an increasing world population. therefore, the purpose of this descriptivecorrelation study was to investigate the effective factors on wheat farmers’ adoption of farming methods of soil management (fmsm). the research instrument ...

Atomic force microscopy has been used to investigate the detachment of single polymer chains from surfaces and to measure the picoNewton forces required to extend the chain orthogonal to the surface. Such recent experiments show that the force-extension profiles provide interesting signatures which might be related to the progressive detachment of the chain from a surface. Using equilibrium sca...

Introduction This module is the eleventh in a series of Extension materials designed to provide Extension agents, Certified Crop Advisers (CCAs), consultants, and producers with pertinent information on nutrient management issues. To make the learning “active,” and to provide credits to CCAs, a quiz accompanies this module. In addition, realizing that there are many other good information sourc...

The adhesion strength of a contact between a rotationally symmetric indenter and an elastic half-space is analysed analytically and numerically using an extension of the method of dimensionality reduction for superimposed normal/tangential adhesive contacts. In particular, the dependence of the critical adhesion force on the simultaneously applied tangential force is obtained and the relevant d...

The identification of proton contacts from NOE spectra remains the major bottleneck in NMR protein structure calculations. We describe an automated assignment-free system for deriving proton contact probabilities from NOESY peak lists that can be viewed as a quantitative extension of manual assignment techniques. Rather than assigning contacts to NOESY crosspeaks, a rigorous Bayesian methodolog...

The folding rates of two-state proteins have been found to correlate with simple measures of native-state topology. The most prominent among these measures is the relative contact order (CO), which is the average CO, or localness, of all contacts in the native protein structure, divided by the chain length. Here, we test whether such measures can be generalized to capture the effect of chain cr...