نتایج جستجو برای: extracellular fluid
تعداد نتایج: 339478 فیلتر نتایج به سال:
The importance of the blood volume in maintaining a normal circulation is now well recognized. The circulation will fail if the volume of blood becomes too small to fill the vascular system adequately. In general, the quantity of blood in the vascular bed is of more significance in maintaining a normal cardiac output than is the proportion of red cells to plasma. Because the volume of plasma ca...
Calcium homeostasis in the extracellular fluid is tightly controlled and defended physiologically. Hypercalcemia always represents considerable underlying pathology and occurs when the hormonal control of calcium homeostasis is overwhelmed. The major hormones that are responsible for normal calcium homeostasis are parathyroid hormone and 1,25-dihydroxyvitamin D; these hormones control extracell...
Generalizability theory was used to investigate the score consistency of observed extracellular fluid/intracellular fluid (ECF/ICF) ratio measurements for both the global and leg-segmental bio-impedance spectroscopy methods. The test instrument used was a Xitron Hydra ECF/ICF Bio-Impedance Analyzer System, model 4200 (Xitron Technologies, San Diego, CA). Fifty able-bodied American men (17 to 72...
CSERR, HELEN. Potassium exchange between cerabrospinal @id, plasma, and brain. Am. J. Physiol. 2og(6): I2Ig--I226* 1965*Potassium exchange between cerebrospinal fluid (CSF), plasma, and brain was investigated in anesthetized dogs and rats using the technique of ventriculocisternal perfusion. Transport via bulk secretion and absorption of CSF accounts for only 20% of total potassium exchange, un...
Drug development targeting the central nervous system (CNS) is challenging due to poor predictability of drug concentrations in various CNS compartments. We developed a generic physiologically based pharmacokinetic (PBPK) model for prediction of drug concentrations in physiologically relevant CNS compartments. System-specific and drug-specific model parameters were derived from literature and i...
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