background: cognitive impairment in patients with parkinson’s disease (pd) mainly involves executive function (ef). the frontal assessment battery (fab) is an efficient tool for the assessment of efs. the aims of this study were to determine the validity and reliability of the psychometric properties of the persian version of fab and assess its correlation with formal measures of efs to provide...

A useful classification of acute leukemia must be reproducible, must impart understanding of leukemogenesis and clinical behavior, and (most importantly) be clinically relevant, which makes such a classification indispensable for designing and comparing clinical trials. Classification systems by their very nature may influence the design of treatment regimens and may even bias investigations of...

Myelodysplastic syndrome (MDS) represents a heterogeneous hematopoietic stem-cell disorder that results in abnormal cellular maturation and peripheral blood cytopenias. MDS is characterized by progressive bone marrow failure, which can lead to bleeding, infections, and complications secondary to anemia. Approximately 35% to 40% of patients diagnosed with MDS progress to acute myeloid leukemia (...

OBJECTIVE To describe and compare diffusion tensor imaging (DTI) parameters between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD) diagnosed using structuralized neuropsychiatric assessments, and investigate potential neuronal substrates related to cognitive performance. METHODS Thirty-five patients with SIVD, 40 patients with AD, and 33 cognitively no...

b a c k ground: several studies have indicated that executive dysfunction is the main neuropsychological feature of parkinson’s disease (pd). the frontal assessment battery (fab) is a short tool for the assessment of executive functions. p u r p o s e : the aim of this study was to determine the relationship between persian version of fab scores and age, education, mini-mental state examination...

abstract background: leukemia is the most common malignancy in childhood, and acute myeloid leukemia (aml) is the second most common leukemia.aml still accounts for more than 30% of deaths from leukemia. aml is classified into several subgroups from m0 to m7 with different presentations, clinical features, and outcomes. material and methods: between march 1996 and october 2003, 47 children with...

human snake bitten poisoning is a serious threat in many tropical and subtropical countries such as iran. the best acceptable treatment of envenomated humans is antivenoms; however they have a series of economic and medical problems and need more improvements. in this study a combinatorial human immunoglobulin gene library against some of iranian snakes venoms was constructed. total rna prepare...

Multidrug resistance (MDR) is a main cause of failure in the chemotherapeutic treatment of malignant disorders. One of the well-known genes responsible for drug resistance encodes the multidrug resistance- associated protein (MRP1). The association of MRP1 with clinical drug resistance has not systematically been investigated in Iranian pediatric leukemia patients. We therefore applied real-tim...