نتایج جستجو برای: factor eight inhibitor bypassing activity

تعداد نتایج: 2125544  

Journal: :Pathophysiology of haemostasis and thrombosis 2003
P L Turecek K Váradi B Keil C Negrier E Berntorp J Astermark J-C Bordet M Morfini S Linari H P Schwarz

Factor VIII (FVIII)-bypassing agents have complex modes of action but all control bleeding in inhibitor patients by triggering the generation of thrombin. No routine test is available for monitoring this therapy in patients with inhibitors against FVIII. We present an assay that records FEIBA- or FVIIa-mediated changes in thrombin generation (TG) in FVIII inhibitor plasma samples. In plasma sam...

Journal: :medical journal of islamic republic of iran 0
hassan mansouri torghabeh from the 'experimental hematology and blood banking dept, medical sciences school, tarbiat modaresuniversity (t.m. u.), ali akbar pourfathollah from the 'experimental hematology and blood banking dept, medical sciences school, tarbiat modaresuniversity (t.m. u.), mahmood mahmoodian shooshtari the iranian blood transfusion organization research center, tehran zahra rezaie yazdi the departmentof internal medicine, mashhad medical sciences university, mashhad habibollah esmaili 4community medicine and public health department of mashhad medical sciences university, mashhad, iran

patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). in this survey we detected factor v and viii inhibitor in ten patients with combined deficiency of factors v and viii from north east of iran (khorassan province). it was revealed in our survey that eight patients had both factor v and factor viii inhib...

ALI AKBAR POURFATHOLLAH, HABIBOLLAH ESMAILI, HASSAN MANSOURI TORGHABEH, MAHMOOD MAHMOODIAN SHOOSHTARI, ZAHRA REZAIE YAZDI,

Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...

2013
Roya Dolatkhah Mohammad Reza Bazavar Masoud Poureisa Iraj Asvadi Kermani Jalil Vaez Gharamaleki Zohreh Sanaat Jamal Eivazi Ziaei Alireza Nikanfar Ali Esfahani Seyed Hadi Chavoshi

The development of inhibitors against administered clotting factors may render replacement therapy ineffective for some hemophilia patients. Such patients are therefore at the highest risk of developing arthropathy. Elective orthopedic surgery (EOS) in hemophilic patients having such inhibitors remains a rare, expensive, and difficult surgery, whose management represents a significant challenge...

2011
Ji Hyun Lee Dong-Hwan Kim Kiyoung Yoo Yongmook Choi Sun-Hee Kim Hee-Jin Kim

Acquired hemophilia A (AHA) is a rare coagulopathy caused by autoantibodies to coagulation factor VIII (FVIII). Most patients with AHA have been previously healthy; however, a variety of morbidities have been associated with the condition including pregnancy. A 40-yr-old woman visited our institution with extensive hematoma on the right hip area. Her medical history revealed no personal or fami...

Journal: :Hamostaseologie 2009
K Thom Christoph Male J Falger I Pabinger

The most serious complication of haemophilia A is development of a high-titre factor VIII (FVIII) inhibitor which renders the patient unresponsive to FVIII replacement. Bleeding complications can only be controlled using FVIII-inhibitor bypassing agents but their effect is less certain. The ultimate goal is to eliminate the inhibitor by immune tolerance induction therapy (ITI) using daily high ...

2015
Hee Young Ju Hye Lim Jang Young Shil Park

BACKGROUND Inhibitory antibodies to factor VIII (FVIII) or IX (FIX) are important issues when managing patients with hemophilia A or B. Advances in bypassing agents such as recombinant activated FVII (rFVIIa) and activated prothrombin complex concentrates (APCC) have enabled the aggressive management of hemophilia with inhibitors during emergency or elective surgery. This study provides an upda...

Journal: :iranian journal of allergy, asthma and immunology 0
hassan mansouri torghabeh aliakbar pourfathollah mahmood mahmoodian shooshtari zahra rezaie yazdi

many investigations have proved relations between abo blood groups with some diseases and factor viii and von willebrand level in plasma. in this study we investigated a relation between abo blood groups and factor viii and ix inhibitors in 102 patients with haemophilia a and 48 patients with haemophilia b. the assay of inhibitor was done by bethesda method. there were no relation between abo b...

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